Molecular Markers in Neuroblastoma
Journal Title: Iranian Journal of Blood and Cancer - Year 2010, Vol 2, Issue 2
Abstract
Neuroblastoma, one of the common malignant childhood tumors, arises from neuroblast cells derived from the neural crest and destined for the adrenal medulla and the sympathetic nervous system and shows remarkable biological heterogeneity, resulting in favorable or unfavorable outcomes. Some tumors make rapid progress with a fatal outcome. In other instances, the tumors regress spontaneously in infants or to differentiate into a benign ganglioneu-roma in older patients. This heterogeneity within neuroblastoma depends on the molecular characteristics of tumor cells. Several distinct genomic alterations have been found in neuroblastoma, including MYCN amplification, DNA ploidy, deletion of the short arm of chromosome 1, gain of chromosome 17q, and deletion of 11q. The difference of expression was also found in genes related to cellular growth, differentiation, and apoptosis of neural network includ-ing signaling by NTRK1 or ALK receptor tyrosine kinases, and telomerase activity. And this presentation discusses diagnostic and prognostic molecular makers for extensive heterogeneity of neuroblastoma. This should lead to more risk-adapted therapies according to the genetic markers by which individual neuroblastomas are biologically charac-terized.
Authors and Affiliations
Eiso Hiyama, Naomi Kamei, Arata Kamimatsuse
Keywords
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