Molecular Mechanisms, Expression and Clinical Role of ErbB Receptors in Endometrial Cancer
Journal Title: International Journal of Clinical Therapeutics and Diagnosis (IJCTD) - Year 2015, Vol 0, Issue 2
Abstract
The epidermal growth factor system (EGF System) is present in various human organs. It has 4 receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands. Especially in cancer, the epidermal growth factor system signaling network becomes hyperactivated with a variety of mechanisms (ligand overproduction, receptor overproduction, constitutive receptor activation). ErbB receptors are trans-membrane glycoproteins. Dimerization of ErbB receptors leads to intracellular kinase activation and initiates intracellular signaling via several pathways. Due to the inactive status of postmenopausal endometrium, we expect to find significantly higher expression of the 4 ErbB receptors in endometrial cancer tissue. In unselected endometrial cancer patients, there is EGFR expression in 43-67% of cases. EGFR overexpression in patients with Type I endometrial cancer, did not affect disease progression. However EGFR overexpression in patients with Type II endometrial cancer, associated with high grade disease and adverse clinical outcome. In unselected endometrial cancer patients, ErbB-2 amplification/overexpression represents a rare event. ΕrbB-2 overexpression especially in patients with Type II endometrial cancer, is an indicator of a highly aggressive disease with poor overall survival. Recent years ErbB receptors (especially EGFR and ΕrbB-2) have a particular importance, as they are potential targets in endometrial cancer treatment.
Authors and Affiliations
Georgios Androutsopoulos
Keywords
Related Articles
- EP ID EP203014
- DOI 10.19070/2332-2926-SI01006
- Views 134
- Downloads 0
Q Fever
A 75-year-old retired farmer living in rural Saskatche-wan, presented with fever, night sweats, and fatigue for three weeks and a two-day history of bilateral calf pain and lower extremity weakness in August. He report-e...
Updates in Vaccines, Viral Therapy and Non-Lymphocytic Immunotherapy for Glioblastoma
A key focus of glioblastoma (GBM) management presently revolves around the cancer’s ability to evade and suppress anti-tumor immune response. Therefore, cancer immunotherapy is a critical area in development and investig...
Intra-maxillary Molecular Releasing and its Application in the Assistance of Neurodegenerative Disease Therapeutics
Neurodegenerative disease (ND) is a complex concept involves multiple pathogenesis including neuronal demyelination, apoptosis under oxidative stress, neuroinflammation with further cortical and spinal atrophy, which may...
Early Results of Ascending Aorta and Aortic Arch Surgery in Albania
Background: Treatment of aneurysms of the ascending aorta, arch aorta, or both are surgically challenging and has traditionally carried a high hospital mortality rate. The use of refined operative techniques has resulted...
Current Status of Cardiovascular Tissue Engineering
The development of vascular and heart valve surgeries have contributed to improve outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Ti...