Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 3
Abstract
Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam. (M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral obesity. Methods: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the mRNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real time-PCR. Results: The results showed that M. oleifera extract down-regulated mRNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ones. Conclusions: It is reasonable to assume that the anti-obesity, anti-atherogenic and antidiabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome.
Authors and Affiliations
Fateheya Mohamed Metwally, Hend Mohamed Rashad, Hanaa Hamdy Ahmed, Asmaa Ahmed Mahmoud, Ehab Ragaa Abdol Raouf, Aboelfetoh Mohamed Abdalla
Keywords
Related Articles
- EP ID EP250415
- DOI 10.1016/j.apjtb.2016.12.007
- Views 114
- Downloads 0
Spatial distribution and infection rate of leishmaniasis vectors (Diptera: Psychodidae) in Ardabil Province, Northwest of Iran
Objective: To determine the spatial distribution and infection rate of sand flies as vectors of Leishmania parasite in Ardabil province, northwest of Iran. Methods: This was a descriptive cross-sectional study. The sand...
Jamun (Syzygium cumini) seed and fruit extract attenuate hyperglycemia in diabetic rats
Objective: To evaluate the potential of both jamun (Syzygium cumini) seed and fruit extracts against hyperglycemia. Methods: Male Sprague Dawley rats were used to evaluate hypoglycemic potential of jamun extracts. Purpos...
Isolation, identification, characterization and antibiotic sensitivity profile of pathogenic Legionella pneumophila isolates from different water sources
Objective: To investigate the prevalence, isolation, identification, characterization, antibiotic profile and pathogenicity of Legionellae isolated from various set of waters. Methods: A total of 400 water samples were c...
In vitro evaluation of anti-acetylcholinesterase and free radical scavenging potential of leaf extracts of some selected medicinal plants
Objective: To evaluate the phytochemical present in various solvent extracts from leaves of Ocimum sanctum (L.), Swertia chirayita (L.), Butea monosperma (Lam.) and Stevia rebaudiana (Bert.) as well as antioxidant and an...
Assessment of pesticide contaminated sediment using biological response of tropical chironomid, Chironomus javanus Kiffer as biomarker
Objective: To investigate the use of a biomarker for assessment of the effects on the tropical chironomid, Chironomus javanus (C. javanus), Kiffer of sediment contaminated with an insecticide (chlorpyrifos). Methods: A w...