Molecular Subtypes in Locally Advanced Breast Cancer-Do They Have a Preferential Destination?
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 12
Abstract
ABSTRACT Introduction: The patterns of relapse in breast cancer are very much driven by the intrinsic molecular subtypes, which have been studied mainly in early stage breast cancer and have prognostic implications. Aim: To explore the relationship between the different molecular subtypes and their predilection to a distinct distant metastatic site in locally advanced breast cancer. Materials and Methods: This was a retrospective review of the records of 70 women with a histopathological diagnosis of locally advanced breast cancer who received radiation therapy between January 2011 and September 2012. Results: In all the molecular subtypes, the most common site of metastasis is the most common first site of distant relapse as well. In luminal A it is the bone, in luminal B the liver and in triple negative and Human epidermal growth factor receptor 2 (HER2/neu) enriched it is the lung. But, the odds ratio was significant only among luminal A patients. There is no significant difference in disease free survival and overall survival between the molecular subtypes. But, luminal subtypes have a longer median survival (25 months) after the development of metastasis compared to non-luminal subtypes (7 months) with a p-value of 0.056. Conclusion: Different molecular subtypes of locally advanced breast cancer have a preferential distant destination and difference in survival post detection of metastasis. A well-structured prospective study protocol with a longer follow up with a larger number of patients is required before tailor made surveillance protocols can be developed for the various molecular subtypes of locally advanced breast cancer.
Authors and Affiliations
Prarthana Roselil Christopher, Pamela Alice Kingsley, Preety Negi, Sudeep Marcus, Jaineet Sachdeva, Clarence Samuel
Keywords
Related Articles
- EP ID EP526388
- DOI 10.7860/JCDR/2018/37446.12373
- Views 86
- Downloads 0
Efficacy of Deferasirox as an Oral Iron Chelator in Paediatric Thalassaemia Patients
Introduction: Thalassaemia Major patients require frequent blood transfusion leading to iron overload. Excessive iron gets deposited in vital organs and leads to dysfunction of the heart, liver, anterior pituitary, pancr...
Factors that Affect the Career and Speciality Preferences of Dentistry Students in Turkey
ABSTRACT Introduction: Many factors may be effective in the career and speciality plans of dentistry students. Graduated students have to make a choice between immediately starting their professional life or choosing a s...
Rectal Necrosis: A Rare Complication of Palliative Radiotherapy for Sacral Spine Metastasis
ABSTRACT Radiation proctocolitis is a common side effect of radiation therapy. In rare cases, chronic radiation injury can be severe enough to cause rectal necrosis. In this study, a case of rectal necrosis after sacral...
Osseous Metaplasia in Oesophageal Leiomyoma-A Rare Case Report
ABSTRACT Amongst benign mesenchymal tumours of the oesophagus, leiomyomas are the commonest. Leiomyomas account for about two-thirds of all benign lesions of oesophagus. Oesophageal leiomyoma of more than 5 cm in diamete...
Comparison of Retropupillary Iris-claw Intraocular Lens Implantation and Transscleral Suture Fixation of an Intraocular Lens for Aphakic Eyes
ABSTRACT Introduction: Iris-claw intraocular lens and scleral-fixation of intraocular lens are the main options for the correction of aphakia with inadequate capsular support. It is still unclear which one is the most ap...