Molecular Targets for Endometriosis Therapy: Where We Are and Where We Are Going?
Journal Title: International Journal of Fertility & Sterility - Year 2019, Vol 13, Issue 2
Abstract
Endometriosis is a chronic hormone-dependent disease, characterized by the presence of endometrial-like glands and stroma outside the uterine cavity. It could occur in distinct phenotypes: peritoneal superficial lesions, ovarian endometriomas and deep infiltrating endometriosis (DIE) (1), which includes various locations penetrating >5 mm under the peritoneal surface. Prevalence of this disease in women of child-bearing age ranges between 6 and 10% (2), but it may also be diagnosed sometimes in menopause. Endometriosis may be responsible for pain symptoms and infertility, which can severely impact the patient’s quality of life (3). Transvaginal ultrasonography is the non-invasive gold standard technique for diagnosing DIE and ovarian endometriomas (4). Magnetic resonance imaging (MRI) can be helpful when the gynecologist is not experienced about ultrasonographic diagnosis of endometriosis or when the findings of ultrasonography are ambiguous (5). Anyway, confirmation of endometriosis diagnosis is only achieved by histological analysis of endometrial stroma and glands.
Authors and Affiliations
Fabio Barra, Antonio Simone Laganà, Jvan Casarin, Lorenzo Ferro Desideri, Carolina Scala, Simone Ferrero
Keywords
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- EP ID EP606112
- DOI 10.22074/ijfs.2019.5736
- Views 156
- Downloads 0
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