Montmorillonite as a drug carrier
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2017, Vol 20, Issue 139
Abstract
The use of clay minerals for medical applications dates back to prehistoric times. Specific properties of this group of minerals, their universality, low cost, ability to ion exchange, absorption capacity, inertness in contact with human tissues as well as their structure, caused that they had been included in the area of interest as potential carriers of medicinal substances in controlled drug delivery systems. At present, clay minerals, in particular montmorillonite, are extensively used in pharmaceutical formulations both as excipients and the active components. The possibility of intercalation of organic compounds, which are drugs among the others, between the layers of montmorillonite, creates new possibilities for the use of this mineral. In the controlled drug delivery systems, the key element is the use of a suitable material for carrier, which primarily must be characterized by a lack of toxicity, good biocompatibility, but also is expected to meet the relevant technological requirements, such as: high efficiency of production and stability in a living organism. The use of a montmorillonite carrier may help to achieve a controlled and sustained release of the drug but also to eliminate the side effects of the drug on the human’s body. Due to the weak van der Waals and hydrogen bonds which exist between montmorillonite layers, it is possible to intercalate the drug particles between the layers and thus forming the impermanent connection to the pharmaceutical. Interest in clay minerals in controlled drug delivery systems is confirmed by the steadily growing number of publications related to this topic. The work is a summary of current knowledge on the use of clay minerals, particularly montmorillonite, in medical applications
Authors and Affiliations
A. Rapacz-Kmita
Keywords
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