More than Expectorant: New Scientific Data on Ambroxol in the Context of the Treatment of Bronchopulmonary Diseases
Journal Title: Journal of Intensive and Critical Care - Year 2017, Vol 3, Issue 3
Abstract
Background:Ambroxol has been established for decades in the treatment of acute and chronic respiratory diseases. A reassessment of the benefit-risk was conducted recently. Objective: What new scientific data, relevant for the treatment of bronchopulmonary diseases, were published in the last decade? Method: Systematic literature search via http://www.pubmed.gov with the search term “ambroxol”, covering the publication period from 2006 to 2015. Nonrelevant publications were excluded manually. Results: 64 relevant publications could be identified covering both, clinical and preclinical research. Conclusion: The traditional indication of ambroxol as an expectorant is confirmed but new results revealed a better understanding of the various mechanisms of action of ambroxol and the benefits for special patient populations. The available data suggest the use of ambroxol as an adjuvant in anti-infective therapy, particularly in case of infections with biofilm-producing pathogens. Lungprotective properties are discussed in both infants and severely ill adult patients. First results in rare diseases, such as lysosomal storage disorders, show a potential benefit of ambroxol. However, final evidence for the clinical relevance in this special field has yet to be provided.
Authors and Affiliations
Manuel Plomer
Keywords
Related Articles
- EP ID EP301008
- DOI 10.21767/2471-8505.100096
- Views 70
- Downloads 0
Coping Patterns in a Mother of a Child with Multiple Congenital Anomalies: A Case Study
Objective: To study the coping pattern of a mother of a child with multiple congenital anomalies (MCAs) based on interview data. Methods: The mother of a child born at Tohoku University Hospital, Japan, who was diagnose...
Is Closed Loop Glucose Control for ICU Patients Just Around the Corner?
Effective glucose control in the Intensive Care Unit (ICU) setting has the potential to lower mortality rates [1], shorten length of stay [2] and decrease overall cost of care [3]. Yet the goal of achieving this control...
A Third of Perioperative Blood Transfusions in the ICU Does Not Follow Guideline Recommendations - A Retrospective Analysis
Objective: This study evaluates the relevance of transfusion guidelines for clinical transfusion practice. Background: There is little data available on current practice related to appropriate use of blood products. Rec...
Brain Death: Past, Present and Future
Sometimes it is been said, that the concept of brain death was “invented” in Boston 1968 for the only purpose of organ donation. – The first part (“past”) clarifies, that the concept of brain death has been elaborated in...
A Retrospective Study on the Compliance with Surviving Sepsis Campaign Guideline in Patients with Sepsis Admitted to Intensive Care Unit in Hong Kong
The global incidence of sepsis is increasing due to earlier recognition, but mortality from sepsis still remains high. Local data on the management according to the Surviving Sepsis Campaign Care Bundle is still lacking....