Moringa oleifera Leaf Prevents Oxidative Stress in Wistar Rats
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 9
Abstract
Background: It is believed now in some group of people that Moringa oleifera is medicinal in nature. People take it in any form to cure various clinical conditions. A number of clinical conditions have been linked to oxidative stress injury. Therefore its mechanism of action may be to control oxidative stress (oxidant-antioxidant status). Objective: It was designed to measured plasma malondialdehyde (MDA), total antioxidant status (TAS) and red blood cell glutathione peroxidase (GPx) of Wistar rat. Materials and Methods: Seventy healthy Wistar rats of both sexes were recruited into the study. Fourty and 30 rats were fed with diet fortified with Moringa oleifera leaf and normal diet respectively for a period of four weeks. Serum (for the measurement of MDA and TAS) and haemolysate (for the measurement of GPx) were prepared from blood sample collected after rats were sacrificed. Variables gotten were analyzed using SPSS version 17, taking level of significance to be 0.05. Results: Serum MDA was observed to be significantly lower in rats fed with Moringa oleifera than those with normal diet (p<0.05). Mean serum TAS as well as red blood cell GPx were found to be significantly higher (p<0.01) in rats fed with Moringa oleifera than those with normal diet. There were negative and positive correlations between ‘MDA and TAS’ and ‘MDA and GPx’ respectively in both study groups. Conclusion: Moringa oleifera leaf may prevent oxidative stress in Wistar rats
Authors and Affiliations
Dolapo Pius Oparinde, Adeniran Samuel Atiba
Keywords
Related Articles
- EP ID EP350195
- DOI 10.9734/EJMP/2014/5126
- Views 102
- Downloads 0
Evaluation of the Anticonvulsant Potential of Aqueous Fraction of Synsepalum dulcificum Seed Extract in Mice
Aim: This study evaluated the anticonvulsant potential of the aqueous fraction of Synsepalum ducificum seed extract in mice. This was with a view to providing information on the possible link between the antioxidant prin...
Ovicidal and Larvicidal Effects of Ricinus communis L. (Euphorbiaceae) Extracts on Phlebotomus duboscqi
Aims: To evaluate the Ovicidal and larvicidal effects of Ricinus communis (Euphorbiaceae) extracts on Phlebotomus duboscqi. Study Design: A comparative experimental design using extracts obtained from the leaf and bark...
Susceptibility Pattern of Plasmid-borne Vancomycin-Resistant Enterococcus faecalis Strains to Selected Nigerian Medicinal Plants
Objective: To determine whether the presence of the resistance factors (plasmids and vanA genes) will negatively aid the susceptibility of vancomycin-resistant Enterococcus faecalis (VREf) to medicinal plants. Materials...
Antioxidant, Antibacterial and Tyrosinase Inhibiting Activities of Extracts from Myristica fragrans Houtt
Aims: To evaluate the antioxidant, antibacterial and tyrosinase inhibiting activities of the methanolic extracts of the leaf and fruit pericarp from Myristica fragrans. Study Design: In vitro assays. Place and Duration...
Role of the Red Fruit (Pandanus conoideus LAM) Ethyl Acetate Fraction on the Induction of Apoptosis vs. Downregulation of Survival Signaling Pathways in Cervical Cancer Cells
Red fruit (Pandanus conoideus Lam) has been used as a traditional herbal medicine in Papua and also as an agent against malignant diseases empirically. To elucidate the detailed mechanisms producing such an activity, the...