Morphine Exposure and Enhanced Depression-like Behaviour Confronting Chronic Stress in Adult Male Offspring Rat
Journal Title: Basic and Clinical Neuroscience - Year 2019, Vol 10, Issue 4
Abstract
Introduction: Opioid addiction is an important concern in the World. Reports demonstrate that substance use disorder could influence genetic and environmental factors, and children of addicts have a higher rate of psychopathology. In this study, we investigated depression-like behavior among offspring of morphine-exposed rat parents. Methods: Adult male and female Wistar rats received morphine for 21 consecutive days and then let them were free of drugs for ten days. Offspring of these rats were divided into three distinct groups: maternal morphine-exposed, paternal morphine-exposed, and both maternal and paternal morphine-exposed. We used sucrose preference and Forced Swim Test (FST) to measure depression-like behavior. Also, we induced chronic mild stress using repeated corticosterone injection and evaluated depression-like behavior in offspring of morphine-exposed parents compared with offspring of healthy ones. Results: Results indicated that depression-like behaviors in the offspring of morphine-exposed rats were higher than those in the offspring of the control group in confronting with chronic mild stress. Additionally, mild chronic stress can produce an exaggerated effect on depression-like behavior in offspring of the morphine-exposed parent(s) compared with those of the control group. Conclusion: Our data support the previous hypothesis that the depression rate is higher in the children of addicts. We verified that even when mother or father was clean of opioid in the time of gestation, their children would be susceptible to depression. Dysregulation of hypothalamic-pituitary-adrenal axis and changing in neuronal features in the hippocampus increased depression-like behavior in the offspring of morphine-exposure parents.
Authors and Affiliations
Anahita Torkaman-Boutorabi, Fereshteh Seifi, Ardeshir Akbarabadi, Heidar Toolee, Mitra-Sadat Sadat-Shirazi, Nasim Vousooghi, Mohammad-Reza Zarrindast
Keywords
Related Articles
- EP ID EP664460
- DOI 10.32598/bcn.9.10.155
- Views 109
- Downloads 0
Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An In Vivo Electrophysiological Study
Introduction: Ventral Tegmental Area (VTA) is a core region of the brainstem that contributes to different vital bio-responses such as pain and addiction. The Dopaminergic (DA) cellular content of VTA has major roles in...
A Hybrid Approach Based on Higher Order Spectra for Clinical Recognition of Seizure and Epilepsy Using Brain Activity
Introduction: This paper proposes a reliable and efficient technique to recognize different epilepsy states, including healthy, interictal, and ictal states, using Electroencephalogram (EEG) signals. Methods: The propose...
The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats
Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an ex...
Commentary on “Co-Occurrence of Pituitary Adenoma With Suprasellar and Olfactory Groove Meningiomas”
Recently, Basic and Clinical Neuroscience published an article by Lim et al. (2016) entitled Co-occurence of Pituitary Adenoma with Suprasellar and Olfactory Groove Meningiomas. They claimed it as the first case of co-o...
Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test
Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main g...