MORPHOFUNCTIONAL STATE OF THE BRAIN HISTAMINERGIC NEURONS OF THE 45-DAY OFFSPRING OF RATS CONSUMING ETHANOL DURING PREGNANCY
Journal Title: Журнал Гродненского государственного медицинского университета - Year 2018, Vol 16, Issue 6
Abstract
Introduction. The consumption of alcohol by the mother during pregnancy disturbs the structure and functions of the offspring brain. Histaminergic neurons of the hypothalamus have not been studied so far. Objective. Estimation of the morphofunctional state of histaminergic neurons in hypothalamic nucleus E2 in the 45-day offspring of rats consuming ethanol during pregnancy. Material and methods. The experiments were performed on white outbred female rats who consumed a 15% ethanol solution during pregnancy, and their 45-day offspring with the use of histological, histochemical, morpho- and cytophotometrical as well as statistical research methods. Results. The 45-day offspring of rats who consumed ethanol during pregnancy, showed a decreased size of the histaminergic neurons bodies, inhibition of succinate dehydrogenase and monoamine oxidase type B as well as activation of acid phosphatase, lactate and glucose-6-phosphate dehydrogenases in their cytoplasm. Conclusions. The consumption of alcohol by female rats during pregnancy disturbs the structure and metabolism of the developing hypothalamic histaminergic neurons of their offspring.
Authors and Affiliations
A. V. Zaerko, K. М. Fedina, S. M. Zimatkin
Keywords
Related Articles
- EP ID EP434425
- DOI 10.25298/2221-8785-2018-16-6-685-689
- Views 118
- Downloads 0
МИНЕРАЛЬНАЯ ПЛОТНОСТЬ КОСТНОЙ ТКАНИ У ЖЕНЩИН МОЛОДОГО ВОЗРАСТА С ЮВЕНИЛЬНЫМ ИДИОПАТИЧЕСКИМ АРТРИТОМ
Введение. На состояние костной ткани у пациентов с ювенильным идиопатическим артритом (ЮИА) влияет наличие хронического системного воспаления и прием глюкокортикоидов. Цель исследования: изучение минеральной плотности ко...
FEATURES OF ENDOMETRIAL STROMA DECIDUALIZATION IN EARLY PREGNANCY LOSS
Background. Decidualization of the endometrial stroma is a multistage process. The immunohistochemical marker of differentiation of decidual cells is desmin. Purpose of the study. The estimation of the prognostic signifi...
ГИСТОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ПОВРЕЖДЕННОГО МЕНИСКА КОЛЕННОГО СУСТАВА
Введение. Посттравматические изменения и регенераторный потенциал ткани находятся в прямой зависимости. В современной литературе изменения мениска коленного сустава у пациентов после травмы изучены недостаточно. Цель. Оц...
OPTIMIZATION OF THE MOLECULAR DIAGNOSIS OF ALLERGIC DISEASES THROUGH THE USE OF CCD-BLOCKERS
Background. The development of methodological approaches aimed to overcome non-specific reactions caused by the presence of antibodies to CCD, in order to assign a rational molecular diagnosis is relevant and economicall...
РЕЦИДИВЫ РАКА КОЖИ ПОСЛЕ БРАХИТЕРАПИИ В РЕЖИМЕ ГИПОФРАКЦИОНИРОВАНИЯ ДОЗЫ И ОДНОКРАТНОГО ОБЛУЧЕНИЯ
Цель работы. Изучить частоту и время развития рецидивов рака кожи после брахитерапии в режиме гипофракционирования дозы и однократного облучения. Материал и методы. Материалом исследования послужили результаты обследован...