Morphofunctional state of the thyroid gland in children with congenital hypothyroidism

Abstract

Background. Diseases of the thyroid gland (TG) are ranked first among all endocrine pathologies and remain one of the most difficult problems. Objective: to evaluate the morphofunctional state of the TG in children with congenital hypothyroidism (CH). Materials and methods. The work is based on survey data of 34 children with CH: ultrasound examination of the TG, determination of thyroid hormone levels (thyroid-stimulating hormone (TSH), free thyroxine, thyroglobulin). Statistical analysis was performed by standard methods using the software package StatSoft Statistica 6.0 for Microsoft Windows XP. Results. In 67.6 % of cases, the diagnosis was established according to the screening for CH, in 32.4 % — out of the screening. In 22 patients, thyroid tissue was not visualized in a typical location, or its total volume was significantly less than normal. In 12 patients, the TG was in typical place, and its volume meet norms or exceeds its upper limit. In 55.6 % of patients, we have detected cysts (in 56 % — with dystopia of the TG, in 44 % of cases — with thyroid hypoplasia). They are located paratracheally: on the left — in 66.7 %, on the right — in 13.3 %, in 20 % — on both sides. It was found a significant degree of thyroid insufficiency in patients with thyroid defects, however, in thyroid hypoplasia, the TSH level was lower (p < 0.05) compared with that of in dystopia. Burdened heredity, mainly maternal, was detected in 11.7 % of patients; almost in a third of cases, the burdened obstetric and gynecological history was observed, more than a half of mothers had abnormal labor, and post-term pregnancy occurred 2.1 times more often than in the general population. Conclusions. The incidence of congenital abnormalities of the TG in children with CH is 64.7 %; more than in half of the cases, we have determined the cysts. Severe degree of thyroid insufficiency has been registered in cases of hypoplasia of the TG.

Authors and Affiliations

T. V. Sorokman, S. V. Sokolnyk, O. V. Makarova, I. I. Meshchyshena

Keywords

Related Articles

An Autoimmune Overlap Syndrome in Diseases of the Thyroid Gland — ​Terra Incognita of Thyroidology

Quite frequent thyroid pathology is an autoimmune disease. However, along with common autoimmune thyroid diseases — ​Graves’ disease, autoimmune thyroiditis, in clinical practice there are autoimmune overlap syndromes, w...

Vitamin D status, frequency of its insufficiency and deficiency in women with polycystic ovary syndrome

Background. Many studies have investigated vitamin D status in women with polycystic ovary syndrome (PCOS), but there is no consensus on whether or not its serum levels are different between women with and without PCOS....

Central Diabetes Insipidus

The lecture presents modern data on epidemiology, etiology, pathogenesis, diagnosis and treatment of central diabetes insipidus.

Disorders of Insulin Synthesis and Secretion in Type 2 Diabetic Suffers after Disaster on ChNPS

There have been demonstrated the results of observation of 60 patients with type 2 diabetes mellitus divided into groups: the I one consisted of participants in the rectification of the consequences of the accident (PRCA...

Prognostic Characteristics of Hypothyroidism Prevalence in the Poltava Region and in Ukraine under Conditions of Iodine Deficiency

Introduction. The increasing interest in the problem of thyroid pathology in recent years is determined by its growing prevalence among the population of Ukraine, and hypothyroidism is one of the most common pathology of...

Download PDF file
  • EP ID EP176186
  • DOI 10.22141/2224-0721.13.1.2017.96755
  • Views 90
  • Downloads 0

How To Cite

T. V. Sorokman, S. V. Sokolnyk, O. V. Makarova, I. I. Meshchyshena (2017). Morphofunctional state of the thyroid gland in children with congenital hypothyroidism. Міжнародний ендокринологічний журнал, 13(1), 45-49. https://europub.co.uk/articles/-A-176186