Morphofunctional state of the thyroid gland in children with congenital hypothyroidism
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 1
Abstract
Background. Diseases of the thyroid gland (TG) are ranked first among all endocrine pathologies and remain one of the most difficult problems. Objective: to evaluate the morphofunctional state of the TG in children with congenital hypothyroidism (CH). Materials and methods. The work is based on survey data of 34 children with CH: ultrasound examination of the TG, determination of thyroid hormone levels (thyroid-stimulating hormone (TSH), free thyroxine, thyroglobulin). Statistical analysis was performed by standard methods using the software package StatSoft Statistica 6.0 for Microsoft Windows XP. Results. In 67.6 % of cases, the diagnosis was established according to the screening for CH, in 32.4 % — out of the screening. In 22 patients, thyroid tissue was not visualized in a typical location, or its total volume was significantly less than normal. In 12 patients, the TG was in typical place, and its volume meet norms or exceeds its upper limit. In 55.6 % of patients, we have detected cysts (in 56 % — with dystopia of the TG, in 44 % of cases — with thyroid hypoplasia). They are located paratracheally: on the left — in 66.7 %, on the right — in 13.3 %, in 20 % — on both sides. It was found a significant degree of thyroid insufficiency in patients with thyroid defects, however, in thyroid hypoplasia, the TSH level was lower (p < 0.05) compared with that of in dystopia. Burdened heredity, mainly maternal, was detected in 11.7 % of patients; almost in a third of cases, the burdened obstetric and gynecological history was observed, more than a half of mothers had abnormal labor, and post-term pregnancy occurred 2.1 times more often than in the general population. Conclusions. The incidence of congenital abnormalities of the TG in children with CH is 64.7 %; more than in half of the cases, we have determined the cysts. Severe degree of thyroid insufficiency has been registered in cases of hypoplasia of the TG.
Authors and Affiliations
T. V. Sorokman, S. V. Sokolnyk, O. V. Makarova, I. I. Meshchyshena
Male factor of sterility: algorithm of laboratory diagnosis of the causes
Timely diagnosis of the causes of infertility is the key to the effectiveness of treatment. Given that half of the causes of this condition accounts for male factor, it is important to conduct a comprehensive study to id...
Influence of Magnesium Ororate on Lipid Metabolism in Patients with Chronic Heart Failure and Concomitant Type 2 Diabetes Mellitus
There was studied the influence of magnesium orotate on lipid metabolism in patients with chronic heart failure in combination with type 2 diabetes mellitus with the purpose of selection of effective complex treatment of...
Phosphorus and Calcium Metabolism in Postmenopausal Women with Diabetes Mellitus: Effects of the Type and Duration of the Disease, Time of Menopause and Body Mass
The article deals with the impact of diabetes mellitus (DM) on the phosphorus and calcium metabolism in postmenopausal women, depending on the type and duration of the disease, duration of menopause, body mass and type o...
Effects of vitamin D on pregnancy, fetal development and children’s health in the postnatal period
A high prevalence of vitamin D insufficiency and deficiency and its negative consequences for health is identified as the area of primary concern for scientists and clinicians worldwide. Observational studies confirm tha...
Influence of Hyperhomocysteinemia Correction on Functional Liver Tests and Lipid Profile in Patients with onalcoholic Fatty Liver Disease in Combination with Type 2 Diabetes Mellitus
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM) are the components of metabolic syndrome, the incidence of which is increasing in the world every year. The article presents the results of treat...