Morphometric and Histopathological Study of Gastric Epithelial Lesions with special reference to proliferative activity
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 6
Abstract
Abstract: Disorders of the gastric epithelium are frequent cause of clinical disease with inflammatory and neoplastic lesions being particularly common. Adenocarcinoma is the commonest gastric malignancy, commonly arising from the antrum or lesser curvature. Morphometry and immuno staining help in classifying different lesions of stomach, specially when there is dilemma in concluding a lesion either benign, premalignant or malignant particularly in small biopsy specimens.The aim is to assess the role of morphometry and proliferative markers in diagnosis of gastric epithelial lesions.In this study, total 100 gastric biopsy specimens from 100 patients were included and analysed by H&E stained sections using morphometric parameters as well as proliferative markers like Ki-67 and proliferating cell nuclear antigen (PCNA).Statistically significant differences found in between the gastric premalignant and malignant epithelial lesions in terms of morphometric parameters and in expression of proliferative markers.Morphometry and immunohistochemistry help in the proper diagnosis of different gastric epithelial lesions particularly those lying in the grey zone on routine histopathological sections. Keywords:Gastric epithelial lesions, morphometry, proliferative activity, Ki-67
Authors and Affiliations
Manisha Sarkar, Sanjiban Patra, Asim Kr. Manna, Mou Das, Rajib Sarkar, Deval Parekh
Keywords
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