Morphometric Assessment of Chronic Inflammatory Cells in Colonic Biopsies of Patients with Irritable Bowel Syndrome
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Introduction: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder which has a complex pathophysiology including the role of inflammation being recently studied. Aim: To assess the role of mast cells and Intraepithelial Lymphocytes (IELs) in IBS patients by morphometry. Materials and Methods: In this study, 148 cases of IBS using the Rome III criteria and 28 controls were taken. IBS patients were divided into two subgroups of Post Infectious (PI) and Non Post Infectious (NPI) subgroups on the basis of past history of episodes of gastroenteritis. All of them underwent full length colonoscopy and biopsy from the descending colon. Histopathology of these two were compared with special attention to morphometric count of IELs by “pin hole” method and mast cells using toluidine blue highlighting. Results: Biopsies were unremarkable in 23(15.54%) patients, whereas 125 (84.46%) patients were diagnosed as Non Specific Colitis (NSC). The difference in IEL counts and mast cell counts were extremely significant (p<0.0001) in controls vs patients, controls vs PI-IBS patients and PI-IBS vs NPI-IBS subgroup whereas the difference was significant (p<0.001) in controls vs. NPI-IBS subgroup. Conclusion: The present study concluded that mast cells and IELs show a significant difference between IBS and non IBS cases, and could have an important role to play in the pathophysiology of IBS.
Authors and Affiliations
Anshul Singh, Anupriya Nautiyal, Shailesh R Patel, Vatsala Misra, SP Misra, Manisha Dwivedi
Keywords
Related Articles
- EP ID EP586010
- DOI 10.7860/JCDR/2019/40569.12852
- Views 79
- Downloads 0
Hemi-Chorea in a Patient with Ketotic Hyperglycemia: An Unusual Presentation
Chorea has often been associated with lesions in the basal ganglia and in the sub thalamic nucleus. It is possible for a patient with chorea-ballismus to have hyperglycemia at the initial presentation. We hereby present...
Idiopathic Charcot’s Arthropathy of Ankle Joint: A Rare Case
ABSTRACT Charcot’s Arthropathy also known as Neuropathic Joint of ankle in a non-diabetic patient is a rare entity. We identified similar case who presented to us with the swelling over left ankle and foot with a dischar...
Histomorphological Spectrum of Duodenal Pathology in Functional Dyspepsia Patients
Introduction: Functional Dyspepsia (FD) is one of the most common causes of gastrointestinal symptoms aetiology of which is poorly understood. Aim: To study duodenal histomorphological features and their relationship wit...
Perceptions of Accredited Social Health Activists Regarding Teenage Pregnancy: A Qualitative Study in a Rural Area of West Bengal, India
Introduction: Teenage pregnancy is one of the most important social and public health problems all over the world. Accredited Social Health Activists (ASHAs) may play a substantial role to reduce the magnitude of the pro...
Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease
Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orphanet. It can present...