MORPHOMETRIC ASSESSMENT OF HUMAN CORPUS CALLOSUM AND ITS CORRELATION WITH AGE AND GENDER- A MRI STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 57
Abstract
BACKGROUND The Corpus Callosum (CC) has been a topic of controversy with regards to the subject of sexual dimorphism. Findings regarding age-related changes are also not same in various studies conducted. Most of the studies have been done on western population with very few on Indian subjects. This MRI study was carried out in South Asian population of Kerala origin with a large sample size of 300 people. The aim of the study is to measure and analyse the age and gender-related differences in the size of human CC with MR imaging of brain. MATERIALS AND METHODS This observational study was done with a sample of 300 normal subjects who underwent MRI scan at the Department of Radiodiagnosis, Government Medical College, Alappuzha. Data was segregated on gender and age basis and various morphometric parameters of CC were statistically analysed using SPSS version 16. RESULTS It was observed that length of CC increased throughout life. Thickness of genu and body were observed to increase up to 45 years, whereas thickness of splenium increased up to 55 years with a decline thereafter. No significant gender differences were found in most of the parameters analysed. CONCLUSION Although, the study consisted of a larger sample, no key sex differences were observed in CC in most of the parameters studied. This suggests that the gender-related differences in connectivity may not be due to gender differences in morphology of CC. Agerelated thinning was observed in anterior part of CC, a decade earlier than its posterior part.
Authors and Affiliations
Veena Nair, Usha Devi Keezhathil Bhargavi
Keywords
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- EP ID EP226176
- DOI 10.14260/Jemds/2017/923
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