Moxibustion at Neiguan acupoint in the prevention of myocardial damage caused by chemotherapy in breast cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 3
Abstract
Objective To investigate the effect of moxibustion on Neiguan acupoint in preventing myocardial damage caused by anthracycline-based chemotherapy in breast cancer patients, and to explore the feasibility of moxibustion on Neiguan acupoint in reducing cardiotoxicity induced by chemotherapy. Methods A total of 80 breast cancer patients who underwent adjuvant chemotherapy with EC-T (pirarubicin + cyclophosphamide followed by docetaxel) regimen after surgery in the Department of Breast Cancer, Shaanxi Provincial Cancer Hospital from May 2020 to May 2021 were selected and divided into control group (n=40) and experimental group (n=40) randomly. During the first four cycles of chemotherapy, both groups received dexrazoxane on the same day as pirarubicin. The experimental group received moxibustion on Neiguan acupoint for three consecutive days starting one day before chemotherapy. The electrocardiograms, cardiac function, levels of cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), and Karnofsky Performance Status (KPS) score were observed before and after four cycles of chemotherapy. Results After four cycles of chemotherapy, the incidences of arrhythmia ［22.5%(9/40) vs 50.0%(20/40), χ2=6.545, P=0.011］ and QRS wave voltage decrease［27.5%(11/40) vs 55.0%(22/40), χ2=6.241, P=0.012］ in the experimental group were lower than those in the control group. The cardiac function classification in the experimental group was better than that in the control group ( Z=2.388，P＜0.017). After four cycles of chemotherapy, left ventricular ejection fraction (LVEF) decreased and left ventricular end-diastolic diameter (LVEDD) increased in the control group, while LVEF and LVEDD changes were not significant in the experimental group. The cTnI levels, NT-proBNP levels, and KPS scores increased in both groups, and LVEF, LVEDD, cTnI, NT-proBNP levels, and KPS scores were better in the experimental group than those in the control group (P＜0.05). Conclusion Moxibustion on Neiguan acupoint has a significant protective effect on myocardial damage caused by chemotherapy in breast cancer patients, and can further improve myocardial function on the basis of dexrazoxane.
Authors and Affiliations
GENG Jie, LI Hua, HE Sai
Keywords
Related Articles
- EP ID EP734505
- DOI 10.13429/j.cnki.cjcr.2024.03.010
- Views 28
- Downloads 0
Trans-segmental shunt surgery for the treatment of syringomeylia resulting from trauma and infection
<b>Objective</b> To investigate the clinical effect of transsegmental shunt surgery in the treatment of syringomyelia due to trauma and infection in perspective of cerebrospinal fluid dynamics.<b>Methods</b> A total o...
Research progress of amino acid metabolism regulating PI3K/AKT/mTOR signaling pathway in gastric cancer
In the tumor microenvironment, amino acids are important nutrients constituting immune cells and tumor cells. Some proteins or key enzymes in the metabolism process are expected to become tumor diagnostic markers or ther...
Association of skeletal muscle mass index with non-traumatic rotator cuff tear in patients with type 2 diabetes mellitus
"<b>Objective</b> To investigate the relationship between skeletal muscle mass index (SMI) and non-traumatic rotator cuff tear(RCT) in patients with type 2 diabetes mellitus (T2DM). <b>Methods</b> The clinical data of...
Advances in metabolic research on gastric cancer and its therapeutic implications
Gastric cancer has extensive metastasis and high mortality, and its pathogenesis has not been fully understood. The advent of metabolomics has further brought metabolic regulation and cancer research into the spotlight....
Correlation of six-minute walking test with lung fuction and quality of life in patients with multimorbidity
Objective To dectect six-minute walking distance (6MWD) of patients with multimorbidity by an intelligent six-minute walking test (6MWT) device, and to investigate the correlation of 6MWD with lung function, quality of l...