MUCOADHESIVE MICROBEADS OF METFORMIN HCL: A PROMISING SUSTAINED DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The present work was investigated to reduce the dosing frequency, improve patient compliance, to improve gastric residence and to decrease GI side effects by designing and evaluating controlled Release Mucoadhesive (CRM) microbeads of Metformin hydrochloride for effective control of diabetes type-II. Microbeads were prepared by employing ionic gelation method by using various natural and synthetic polymers such as sodium alginate as main polymer and sodium carboxy methyl cellulose(SCMC), carboxy methyl cellulose(CMC), methyl cellulose (MC), poly vinyl pyrrolidine (PVP) as co-polymers which mainly containing mucoadhesive property. These polymers are used with various proportions using calcium chloride as across linking agent. The mucoadhesive property of four polymers is in the following order (SCMC > CMC > MC > PVP).Twenty formulations were prepared. The mucoadhesive beads were characterized for micromeritic properties such as bulk density, tapped density, hausner’s ratio, compressibility index, angle of repose, percentage drug content, entrapement effieciency, swelling index, In-vitro drug release, mucoadhesion test, drug kinetics and FT-IR studies. The drug entrapment efficiency increased progressively with increasing concentration of co - polymer resulting in the formation of larger microbeads entrapping greater amounts of the drug. No significant drug-polymer interactions were observed in FT-IR studies. The kinetics of drug release and their mucoadhesive nature in vitro using goat intestinal mucosa was also investigated at physiological pH 1.2 HcL. The effective mucoadhesion property with controlled release profile was observed from optimized mucoadhesive beads consisting of Sodium alginate and SCMC (1:5). The prepared microspheres exhibited prolonged drug release as the concentration of co-polymer increased, as the SCMC polymer concentration increases the mucoadhesion increased and the drug release rate decreased at higher concentration of sodium alginate.
Authors and Affiliations
Samyuktha Rani, Brahma Reddy, Lakshmi Sai, Lakshmi K. , Vasavi chandrika
Keywords
Related Articles
- EP ID EP114306
- DOI -
- Views 110
- Downloads 0
ANTI-OBESITY AND HYPOLIPIDEMIC ACTIVITY OF METHANOL EXTRACT OF TABERNAEMONTANA DIVARICATA ON ATHEROGENIC DIET INDUCED OBESITY IN RATS
Tabernaemontana divaricata (Fam- Apocynaceae) is traditionally used for various treatments and also in the cases of arteriosclerosis and circulatory irregularities. Hence the present investigation was designed to evaluat...
SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF RABEPRAZOLE SODIUM IN TABLETS
A simple, rapid, accurate, economical and reproducible spectrophotometric method for estimation of rabeprazole sodium (RAB) has been developed. The method employs estimation by straight line equation obtained from calibr...
EVALUATION OF PHYTOCHEMICAL CONSTITUENT IN CONVENTIONAL AND NON CONVENTIONAL SPECIES OF CURCUMA
Plants and plant based medicaments are the basis of many of the modern pharmaceutical we use today for our various aliment. Plant show medicinal properties as it contain phytochemical constituent. Phytochemical constitue...
COMPARATIVE STUDY ON THE EFFECTS OF AQUEOUS AND ETHANOL LEAF EXTRACTS OF CASSIA ALATA LINN ON SOME PATHOGENIC BACTERIA AND FUNGI
The plant Cassia alata linn is a shrub that has various uses ranging from mild to severe infectious and non-infectious diseases. The study was aimed at comparing the antimicrobial activities of the aqueous and ethanolic...
VALIDATION AND PROCESS DEVELOPMENT: A REVIEW
Total Quality Management and specifications according to regulatory guidelines involved in pharmaceutical production has a great impact significantly on the quality of the products. The validation protocol includes inven...