Mucoepidermoid Carcinoma of Salivary Gland: An Elusive Cytology
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 4
Abstract
Context: Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands accounting for 5–10% being more common in the parotid gland, followed by minor salivary glands, especially palate. It is one of the most problematic tumours due to elusive features. FNAC is a valuable tool to preoperatively assess surgical management. However due to its morphological heterogeneity, overlapping architectural patterns and nuclear features a high false negative rate is seen. Aims: To elucidate the cytomorphological features of MEC. To explore the accuracy and pitfalls of FNAC in MEC by comparing it with final histopathological diagnosis. Methods and Material: This retrospective study was conducted on 15 cases of salivary gland lesions which were diagnosed as MEC on FNAC or later from biopsy/excision specimens by histopathology. The case details and slides were retrieved from the archives for a 10 year period (2006–2015). The cytological features were compared with the final histopathological diagnosis. Results: Out of 15 cases, 7 cases were concordant while 8 cases were found to be discordant with the final histopathological diagnosis. Underdiagnosis and overdiagnosis were noted and the overall diagnostic accuracy was 46.6%. Conclusions: This study of salivary gland tumours emphasizes the inherent problems in cytologic diagnosis of MEC as low & intermediate grade lesions are commonly underdiagnosed as benign.
Authors and Affiliations
Supriya Verma
Keywords
Related Articles
- EP ID EP670629
- DOI 10.21088/ijprp.2278.14810.8519.24
- Views 101
- Downloads 0
Rainbows of Ovarian Lesions in Department of Pathology in a Tertiary Care Hospital
Background: Histopathological examination remains the gold standard for diagnosis of ovarian tumours. Morphological diversity of ovarian tumours poses many challenges in diagnosis. It is important to have knowledge regar...
Lipid Profile and Investment of Oxidants and Antioxidants in Hypertension and Ischemic Heart Disease of Tribal and Non-Tribal Patients
Introduction: Hypertension (HT) and Ischemic Heart Disease (IHD) are two pandemic cardiovascular health problems. The alarming feature of 1HD is that majority of burden is now shifting to developing and deprived economie...
A Case- Control Study on Hematological Profile in Thyroid Dysfunction
Introduction: Thyroid hormones regulate hematopoiesis and as a result hematological abnormalitites can occur in thyroid dysfunctions. But these are rarely studied and we attempted to evaluate hematological profile in th...
A Study of Multiple Congenital Anomalies in Fetus and Neonates
Background: Congenital Anomalies are one of the leading causes of paediatric mortality in developed & developing countries. Based on World Health Organization 3 million fetuses and infants are born each year with congeni...
Follicular Lesions of Thyroid Cytopathology-Diagnostic Pitfalls
Context: Fine-needle aspiration (FNA) is well known non invasive tool for diagnosis of thyroid nodules thereby drastically reducing the number of surgeries. However the most common limitation of FNA is in follicular les...