Mucosal copper and zinc levels in oral submucous fibrosis patients
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 3
Abstract
Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease and a premalignant condition of the oral cavity. Of late, a renewed interest in the role of copper and zinc as a mediator of fibrosis in OSMF has been postulated. Hence; we planned the present study to assess the role of mucosal copper and zinc levels in OSMF patients. Materials & methods: The present study was carried on the patients that were diagnosed histopathologically as Oral Submucous Fibrosis (OSMF). A total of 40 cases of OSMF and 20 cases of without any lesion and habit (normal control) were included in the present study. The preserved tissue samples were weighed initially and an aliquot was prepared by dissolving it in 1ml concentrated nitric acid. This aliquot was then diluted with 2 ml deionized water. For the copper estimation a dilution in the ratio of 1:1 of the solution was used and a ratio of 1:5 for zinc estimation. Estimation of the copper and zinc content was achieved by the colourimetric method. The absorbance of these samples was compared to that of the standard solution provided in the kits at 578 nm in a digital photometer. All the results were analyzed by SPSS software. Results: While comparing mean mucosal copper and zinc levels in between OSMF patients and normal controls, we obtained significant results. Conclusion: Crucial role is played by copper and zinc in the pathogenesis of OSMF.
Authors and Affiliations
Jasmin Singh, Sanjeet Singh
Keywords
Related Articles
- EP ID EP505694
- DOI -
- Views 105
- Downloads 0
Aesthetic Rehabilitation of the Patient with Enamel Hypoplasia and Malformation in Anterior Teeth
In order to prevent enamel hypoplasia and malformation in anterior teeth, direct composite veneers applications have become quite popular as minimally invasive and conservative treatment. Problems like discoloration, mic...
Association of ABO Blood Group and Malaria
Background: Malaria is an infection caused by intracellular protozoan parasites of the genus Plasmodium and transmitted by the bite of infectedfemale Anopheles mosquitoes. The present study was conducted to evaluate asso...
PROBIOTICS: BEING HEALTHY IN A NATURAL WAY
The development of resistance to a range of antibiotics by some important pathogens has raised the possibility of a return of humans to the pre-biotic dark ages. The time has come to shift the paradigm of treatment from...
MICROBIOLOGICAL PROFILE IN URINARY TRACT INFECTIONS AMONG CHILDREN
Background: Urinary tract infection (UTI) is a typical bacterial contamination in kids. Early determination, treatment in light of the anti-microbial affectability example of the causative microorganisms and assessment f...
A Clinical Study of Anterior Segment Ocular Manifestations in Blunt Trauma to the Eye
Background: Blunt trauma forms a chief part of ocular trauma. Cricket balls, Road traffic accidents, Assault, elastic luggage straps, falls and animal tail or horn are the most common causes of blunt ocular trauma. Aim o...