Multi-Factorial Causes of Torsade De Pointes in a Hospitalised Surgical Patient
Journal Title: Sultan Qaboos University Medical Journal - Year 2013, Vol 13, Issue 1
Abstract
A 55-year-old chronic alcoholic male known to be positive for human immunodefciency virus (HIV) was admitted to a surgical ward following perianal abscess drainage. He was noted to have sinus bradycardia, ventricular premature complexes, and mild hypotension. His laboratory investigations revealed mild hypokalaemia. He was intermittently agitated and alcohol withdrawal syndrome (AWS) was diagnosed. Postoperatively, he received intravenous piperacillin/tazobactam and metronidazole infusions along with a small dose of dopamine. Analysis of a 24-hour Holter monitor (ECG) showed a prolonged QT interval with two episodes of self-terminating torsade de pointes. His AWS was treated, hypokalaemia was corrected, and dopamine, along with antibiotics, was withdrawn. Tere was no recurrence of arrhythmias. Tis case highlights the importance of avoiding QT-prolonging drugs in hospitalised patients, since hospitalised patients often have multiple risk factors for a proarrhythmic response.
Authors and Affiliations
Prashanth Panduranga| Departments of Cardiology, Royal Hospital, Muscat, Oman, Mohammed Al-Mukhaini| Departments of Cardiology, Royal Hospital, Muscat, Oman, Mamatha P. Rajarao| Departments of Emergency Medicine, Royal Hospital, Muscat, Oman
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