Multicenter Study of Infectious and Noninfectious Endophthalmitis after Intravitreal Ranibizumab Injections
Journal Title: Journal of Addiction & Prevention - Year 2014, Vol 2, Issue 1
Abstract
Study background: The purpose of this study is to evaluate the overall incidence of infectious and non infectious endophthalmitis associated with intravitreal ranibizumab (IVR) injections. Methods: This is a retrospective, consecutive, multicenter case series involving six large clinical sites. The number of injections was determined from the injection log books and billing records. Cases of clinical diagnoses of endophthalmitis or suspected endophthalmitis resulting from IVR injection were identified and reviewed. From these data, the risk per injection was estimated. Results: A total of 7,178 IVR injections were administered on 1,372 patients from January 1, 2007 to July 31, 2010. In this series, the incidence of clinically-suspected and culture-positive infectious endophthalmitis was 3 cases for total number of 7,178 IVR injections (0.042%), whereas the incidence of clinically-suspected and culture-negative infectious endophthalmitis was only 1 case (0.014%), and the incidence of sterile noninfectious endophthalmitis was also 1 case (0.014%). The clinical course was favorable in all patients. Posteriorly, three of the patients received other IVR injections with no complications. Conclusion: The rate of culture-proven endophthalmitis associated with IVR injections is low, with an incidence of approximately 1 in 2,392 injections. The prognosis is good and patients with this complication do well, typically with a return to baseline vision.
Authors and Affiliations
Francisco J Ascaso
Keywords
Related Articles
- EP ID EP194863
- DOI 10.13188/2334-2838.1000014
- Views 124
- Downloads 0
Children of Substance Abusing Parents: Child Behavior Data of Brazilian Service
Determining the relevant risk factors and protective factors as well as the correlation between them is an important tool for preventing substance abuse. A case-control study of addiction and its risk factors was perform...
Impact of substance use on the Australian workforce
Objective: To determine the prevalence of substance use and related problems in the Australian workplace. Methods: We investigated two waves of data from a large nationally representative survey including descriptive an...
Prevention of Opioid Use Disorders for Veterans with Chronic non Cancer Pain and PTSD
Psychological trauma is a major predictor of opioid dependence, with the risk of intravenous drug use being increased nine-fold in individuals with a history of early trauma [1] and a co-morbid rate of 33% in adults with...
The Trabecular Meshwork: A Basic Review of Form and Function
IOP is a consequence of aqueous humor inflow balanced against aqueous humor outflow and both are approximately 2.75 μl/min [10]. Inflow is relatively pressure insensitive until very high pressures are achieved [11]. IOP...
Cannabis and Harm Minimisation Drug Education: Findings from the Drug Education in Victorian Schools Study
Aims: To evaluate the effectiveness of an integrated harm minimisation focused school drug education programme in terms of reducing cannabis use and harm. Design and Methods: A cluster randomised controlled trial of the...