Multicenter Study of Infectious and Noninfectious Endophthalmitis after Intravitreal Ranibizumab Injections
Journal Title: Journal of Ocular Biology - Year 2014, Vol 2, Issue 1
Abstract
Study background: The purpose of this study is to evaluate the overall incidence of infectious and non infectious endophthalmitis associated with intravitreal ranibizumab (IVR) injections. Methods: This is a retrospective, consecutive, multicenter case series involving six large clinical sites. The number of injections was determined from the injection log books and billing records. Cases of clinical diagnoses of endophthalmitis or suspected endophthalmitis resulting from IVR injection were identified and reviewed. From these data, the risk per injection was estimated. Results: A total of 7,178 IVR injections were administered on 1,372 patients from January 1, 2007 to July 31, 2010. In this series, the incidence of clinically-suspected and culture-positive infectious endophthalmitis was 3 cases for total number of 7,178 IVR injections (0.042%), whereas the incidence of clinically-suspected and culture-negative infectious endophthalmitis was only 1 case (0.014%), and the incidence of sterile noninfectious endophthalmitis was also 1 case (0.014%). The clinical course was favorable in all patients. Posteriorly, three of the patients received other IVR injections with no complications. Conclusion: The rate of culture-proven endophthalmitis associated with IVR injections is low, with an incidence of approximately 1 in 2,392 injections. The prognosis is good and patients with this complication do well, typically with a return to baseline vision.
Authors and Affiliations
Francisco J Ascaso
Keywords
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- EP ID EP197772
- DOI 10.13188/2334-2838.1000014
- Views 117
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