MULTIDRUG LOADED GASTRORETENTIVE FILMS FOR THE TRATMENT OF H. PYLORI INFECTION
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 3
Abstract
The objective of the present work was to develop innovative gastro retentive formulation based on mucoadhesive patch systems using the solvent casting technique, allowing a final structure with improved cohesion by mucoadhesive swelling and which releases drugs in the stomach. Chitosan used as a natural polymer, and PAA is a mucoadhesive polymer. The mucoadhesive gastro retentive films bearing amoxicillin trihydrate, metronidazole and famotidine were prepared using solvent casting method. This method provides good drug content uniformity. Various formulation variables i.e. percentage of glycerol plasticizer, concentration of chitosan and chitosan : PAA ratio, which affects the GR films preparation and its characterization were optimized on the basis of their effect on film weight, thickness, folding endurance and tensile strength. The various variables were optimized by varying one variable and keeping other variable constant.
Authors and Affiliations
Sapna Rathore*| Department of Pharmacy, Oriental University, Indore –India, M K Gupta| Department of Pharmacy, Oriental University, Indore –India, Neetesh Kumar Jain| Department of Pharmacy, Oriental University, Indore –India, Ankita Dubey| Department of Pharmacy, Oriental University, Indore –India, Ankit Agrawal| Department of Pharmacy, Oriental University, Indore –India
Keywords
Related Articles
- EP ID EP3569
- DOI -
- Views 330
- Downloads 19
Clinical Indications of Hematopoietic Stem Cell Transplantation: A Clinical Review
Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor cells that develop from mesodermal hemangioblast cells. All differentiated blood cells from the lymphoid and myeloid lineages arise from HSCs. H...
SYNTHESIS AND CHARACTERIZATION OF pH SENSITIVE PHARMACEUTICAL POLYMERS FOR CONTROLLED DRUG DELIVERY SYSTEMS.
The Pharmaceutical industry is evaluating modes of delivery for their prized therapeutics at every step of the design cycle. In recent years, pH dependent drug delivery systems have focused much for specific purposes. S...
A PREDICTIVE MODEL FOR ETHNOMEDICINAL DISCOVERY RESEARCH- A NIGERIAN CASE STUDY
Using a model parametrically dependent on a number of research factors we have examined the relationship between ethnomedicinal drug discovery research in Nigeria and the goal of advancing drug candidates into preclinica...
Evaluation of Brain Targeting of Drugs after Administered Intranasally
Intranasal route has potential to target brain and possesses several advantages over parenteral and oral routes in treating CNS disorders such as stroke, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, epil...
HEMATOPOIETIC GROWTH ASPECTS: MANIFESTATION OF VULNERABILITIES AND PROSPERITY IN HUMAN CANCER
A regular reaction of cancer medicine is bone marrow concealment. The resulting myelosuppression and iron deficiency can cause huge morbidity and mortality for patients. Mediators, for example granulocyte colony stimul...