MULTIDRUG RESISTANCE IN PSEUDOMONAS AERUGINOSA: A GENERAL OVERVIEW.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 5
Abstract
Pseudomonas aeruginosa, a gram-negative bacillus, is a multidrug resistant (MDR) pathogen posing a threat to hospitalised patients and contributes to their morbidity and mortality. This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of β-lactamases and efflux pumps, combined with low permeability of the outer-membrane) or following acquisition of resistance genes (e.g., genes for β-lactamases, or enzymes inactivating aminoglycosides or modifying their target), over-expression of efflux pumps, decreased expression of porins, or mutations in quinolone targets. There has been an accelerated increase in multidrug resistant strains of this organism while the available therapeutic options are severely limited. There is a need for new agents that can overcome the multidrug resistance of these organisms when the available therapeutic options become restricted. This review discusses about various mechanisms of multidrug resistance and possible novel therapeutics introduced from time to time.
Authors and Affiliations
Abbas Omran.
Keywords
Related Articles
- EP ID EP296891
- DOI 10.21474/IJAR01/7087
- Views 78
- Downloads 0
DIFFERENTIATION OF RENAL AML (ANGIOMYOLIPOMA) WITH MINIMAL FAT FROM RCC (RENAL CELL CARCINOMA) BY ANALYSIS ON CT IMAGES.
International Journal of Advanced Research (IJAR)
INVESTIGATING THE PRODUCT QUALITY ATTRIBUTES THAT INFLUENCE CUSTOMERS SATISFACTION OF ONLINE APPARELS.
This study has investigated the product quality attributes that influence customers satisfaction of online apparels. This study adapted a model from Garvin (1984) in measuring product quality which consist of eight varia...
RADIX VISTA: A CASE SERIES.
With the increasing number of reports of aberrant root canal morphology, the clinician needs to be aware of the variable anatomy.Normally the permanent mandibular first molar has two roots, mesial and distal, but mandibu...
AN ENHANCEMENT REVIEW ON IMAGE SEGMENTATION METHODS.
Image segmentation is one of the chief issues in image processing functions and it is challenged by intensity, variation in images and noises. The researchers are continued on the image segmentation way to induce the per...
IMPORTANCE OF BODY MASS INDEX (BMI) IN SCHOOL CHILDREN.
Introduction: Obesity is increasing at an alarming rate throughout the world. By creating awareness on obesity and its effects on health to students, we not only prevent many medical conditions like diabetes, high blood...