Multidrug Resistant Acinetobacter in Patient with Ventilator Associated Pneumonia: Review Article
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2019, Vol 8, Issue 3
Abstract
Acinetobacter is a complex genus, with multiple species. Acinetobacter species are the common etiology of nosocomial infections, principally nosocomial pneumonia catheter-associated bacteremia and urinary tract infections. Multidrug Resistant (MDR) Ventilator Associated Pneumonia (VAP) by Acinetobacter spp is increasingly reported from different parts of the world. Transmission of Acinetobacter is aid by the organism's environmental stubbornness, resistance to desiccation and evasion of host immunity. The virulence properties demonstrated by Acinetobacter spp. is primarily by evasion of rapid clearance by the immune system. The capsular polysaccharide is a critical virulence factor that enables immune evasion and lipopolysaccharide triggers septic shock. Conversely, the primary factor of clinical outcome is antibiotic resistance. Acinetobacter spp. has become a discreditable threat for patients on mechanical ventilation. Considering high rate of antibiotic resistance, new preventive and therapeutic alternative approach for MDR Acinetobacter spp. infections are urgently needed. Worldwide drug resistance in Acinetobacter baumannii is growing. This review article is emphasised on incidence of VAP due to MDR Acinetobacter, phenotypes, genotypes, associated risk factors and preventive strategy.
Authors and Affiliations
Harsha V. Patil, Shivaji T. Mohite, Virendra C. Patil
Keywords
Related Articles
- EP ID EP629925
- DOI -
- Views 92
- Downloads 0
Caesalpinia bonduc Linn Extracts Exhibit Hepatoprotective Effect on HepG2 Cells against Paracetamol by Up-regulating Glutathione Related Genes
Background: Caesalpinia bonduc (CB) is said to own various pharmacological and therapeutic application against a number of diseases. It is used widely in folk medicine to treat liver diseases. In the present study, we ha...
Homotypic Cell Cannibalism and Cannibalism Index-A Four Year Study in Inltrating Ductal Carcinoma Breast
Background: Homotypic cell cannibalism is a hallmark of malignant lesions. It serves as an emerging indicator of both the anaplastic grade and invasiveness. Aim and Objectives: The present study was conducted to corr...
Relevance of Vascular Sciences Research
-
In Vitro Biofilm Formation by Uropathogenic Bacteria and their Antibiotic Susceptibility Pattern
Background: Uropathogens have an ability to form biofilm in urinary tract. Microorganisms growing in biofilm are associated with chronic and recurrent UTI. They are highly resistant to a variety of antimicrobial agen...
Clostridium difficile in Antibiotic-Associated Diarrhoea and Detection of Toxin Producing Strains in a Tertiary Care Hospital in Western Maharashtra
Background: Rampant and injudicious use of broad spectrum antibiotic in hospitalized patients has increased the incidence of Clostridium difficile Associated Diarrhea (CDAD). In recent years, Clostridium difficile Infect...