Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-011-9287-4) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Roberto Bizzotto, Stefano Zamuner, Enrica Mezzalana, Giuseppe De Nicolao, Roberto Gomeni, Andrew C. Hooker, Mats O. Karlsson
Selected physical and chemical properties of commercial Hypericum perforatum extracts relevant for formulated product quality and performance
Objective. The complex composition-activity relationship of botanicals such as St John's Wort (SJW) presents a major challenge to product development, manufacture, and establishment of appropriate quality and performance...
Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges
Various drug delivery approaches can be used to maximize therapeutic efficacy and minimize side effects, by impacting absorption, distribution, metabolism, and elimination (ADME) of a drug compound. For those drugs with...
Cetirizine from topical phosphatidylcholine-hydrogenated liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model
Cetirizine, an effective, minimally sedating, second-generation H1-antihistamine is widely used orally to treat allergic skin disorders. This study was performed to assess the peripheral H1-antihistaminic activity and ex...
Pilot and Repeat Trials as Development Tools Associated with Demonstration of Bioequivalence
The online version of this article (doi:10.1208/s12248-015-9744-6) contains supplementary material, which is available to authorized users.
Summary of Confirmation Cut Point Discussions
A subgroup of AAPS NBC Immunogenicity Workshop attendees met to discuss the current recommendations in white papers and guidance documents, to describe and discuss current practices, and to resolve concerns as to the bio...