Multiparameter Flow Cytometry: An Important Auxiliary Tool for The Diagnosis and Differential Diagnosis of Myelodysplastic Neoplasms
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1
Abstract
Multiparameter flow cytometry (MFC) shows promise in the diagnosis and differential diagnosis of myelodysplastic neoplasms (MDS). By identifying abnormal immunophenotypes of different cell lineages in bone marrow (BM) cells, MFC can aid in the differential diagnosis of some bone marrow failure diseases. Several flow cytometry scoring systems have been established based on current parameters, but there is still no specific immunophenotype available for the diagnosis of MDS. Morphological examination of cells remains the gold standard for MDS diagnosis. In the future, identifying specific cell immunophenotypes may improve MDS diagnosis and alter the use of MFC. MFC may also provide a solution for tracking the evolution of specific abnormal hematopoietic clones in MDS.
Authors and Affiliations
Siqi Luo, Rong Huang, Shifeng Lou
Keywords
Related Articles
- EP ID EP740145
- DOI 10.54457/DR.202301005
- Views 51
- Downloads 0
Significance of Liquid Biopsy Containing Circulating Tumor DNA (ctDNA) Analysis for Evaluation and Management of Metastatic Cancer
According to the GLOBOCAN 2020 data from WHO, nearly 10 million deaths took place due to cancer thus, cancer became a leading cause of death all over the world. The most common cancer are breast cancer, lung cancer, colo...
ADAMTS Proteases: Their Multifaceted Role in the Regulation of Cancer Metastasis
Cancer leads to nearly 10 million deaths worldwide per year. The tumour microenvironment (TME) is fundamental for tumour growth and progression. A key component of the TME, the extracellular matrix (ECM) has recently bec...
Updating CAR-T Cell Immunotherapy for Liquid and Solid Tumor
According to the GLOBOCAN 2020 report, there is still a 50% mortality rate observed in cancer patients despite the availability of various innovative cancer therapies. This highlights the need for specific therapies that...
Is Preoperative Radiotherapy Necessary for Resectable Locally Advanced Squamous Cell Esophageal Carcinoma?
Based on the guidelines for esophageal and esophagogastric junction cancers, the standard of care for resectable locally advanced (cT2, N0 [high-risk lesions: lymphovascular invasion, ≥3 cm, poorly differentiated]; cT1b-...
Dendritic Cell Subsets: The Next Target for Pregnant Complications?
Dendritic cells (DCs) are professional antigen-presenting cells with both immune stimulatory and regulatory functions. DCs are critical players in pregnancy, whose dysregulation is associated with multiple pregnancy-rela...