Multiparametric MRI Fusion-guided Biopsy for the Diagnosis of Prostate Cancer: Results of the First 100 Consecutive Patients
Journal Title: The Bulletin of Urooncology - Year 2021, Vol 20, Issue 1
Abstract
Objective: Our aim was to compare prostate cancer detection rates according to International Society of Urological Pathology (ISUP) grade group (GG) among magnetic resonance imaging (MRI)-targeted biopsies (TBx), systematic biopsies (SBx) and a combination of both (TBx + SBx). Materials and Methods: Between July 2018 and Nov 2020, 100 patients undergoing MRI-targeted prostate biopsy and SB were analysed retrospectively. Men with MRI-visible prostate lesions underwent both MRI-targeted (UroNav®) and systematic 12-core biopsy. The primary outcome was cancer detection according to ISUP GG. The secondary outcome were detection of cancers of GG 2 or higher. Results: The overall cancer detection rate in the study was 43%. Among these, a histopathological ISUP grade of 1 was detected in 44.2%, ISUP grade 2 in 32.5% and higher-grade groups in 23.2% of patients. MRI-TB detected 38 and SBx biopsy detected 30 of the overall study cohort. Combined biopsy led to a cancer diagnoses in 18 more men than with either method alone. Significant cancer detection was 53.4% for TBx, 39.5% for SBx, and highest 55.8% for combination TBx + SBx (p=0.038). Most of the cancers missed by SBx were clinically significant. No significant side effects were recorded. The overall cancer detection rate was 20.4%/46.6% and 90.2% for prostate imaging reporting and data system 3/4/5, respectively. Conclusion: Our results have shown that among patients with lesions visible on MRI, combined biopsy led to greater detection of all prostate cancers, providing increased detection of clinically significant tumours.
Authors and Affiliations
Güven Aslan
Keywords
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- EP ID EP693529
- DOI 10.4274/uob.galenos.2020.1748
- Views 96
- Downloads 0
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