MULTIPARTICULATE DRUG DELIVERY SYSTEM FOR COLON TARGETING

Abstract

Objective: The objective of the present investigation was to design a multi particulate delivery system for site-specific delivery of 5-aminosalicylic acid (ASA) using natural polysaccharides (pectin) and pH-sensitive polymer (Eudragit S100) for the treatment of ulcerative colitis. This system is anticipated to protect the drug loss in the upper GI tract, which results from the inherent property of Eudragit S100 (ES), and deliver ASA in the colon only.Methods: The use of enteric polymers (ES) as the protective coating on the microspheres makes them able to release the drug at the particular pH of colonic fluid. A combined mechanism of release is used, which combines specific biodegradability of polymer and pH-dependent drug release from the coated microspheres. The effects of polymer concentration, stirring rate, and concentration of emulsifier on particle size and drug loading were studied. Pectin microspheres were prepared by emulsion dehydration method using different ratios of drug and polymer (1:2 to 1:4), stirring speeds (1000-3000 rpm) and emulsifier concentrations (1%-3% wt/vol). Eudragit -coating of pectin microspheres was prepared by oil-in-oil solvent evaporation method. Both the pectin microspheres and Eudragit-coated pectin microspheres were evaluated for surface morphology, particle size and size distribution, percentage drug entrapment, swell ability and In vitro drug release in pH progression media.Result: The release profile of 5-ASA from Eudragit-coated pectin microspheres was pH dependent. Hence, the drug released quickly at pH 7.5 but the release rate was much slower in acidic medium.Conclusion: The designed drug delivery system can be used as a tool for colon targeting of drugs.

Authors and Affiliations

Sangeeta Mohanty, Amit Kumar Panigrahi

Keywords

Related Articles

PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF WARFARIN SODIUM 5 MILLIGRAMS TABLET IN HEALTY THAI SUBJECTS

Objective:  The present study aimed to evaluate the bioequivalence between the generic warfarin sodium tablet and a reference product when gave as equal labeled doses in healthy Thai subjects under fasting condition.Met...

DESIGN AND STATISTICAL OPTIMIZATION OF ANTACID ANALGESIC EFFERVESCENT TABLETS BY USING 2^3 FACTORIAL DESIGN

Objective: The present research work was undertaken with an aim to formulate a combination dosage form constituting an antacid and analgesic which may be useful in case of hyperacidity associated headache.Methods: In thi...

ROLE OF NITRIC OXIDE (NO) IN CAPSAICIN MEDIATED ANTI-PLATELET ACTIVITY IN IN VITRO, IN VIVO, EX-VIVO MODEL OF PLATELET AGGREGATION ASSAY AND ARTERIAL THROMBOSIS IN RAT: POTENTIAL THERAPEUTIC TARGET?

Objective: Although recent advances in the treatment of congestive heart disease, mortality among patients’ remains a questionable remark. Therefore, we evaluated the role of capsaicin on in vitro and ex vivo platelet...

ANTI-INFLAMMATORY AND PROTECTIVE PROPERTIES OF ALOE VERA LEAF CRUDE GEL IN CARRAGEENAN INDUCED ACUTE INFLAMMATORY RAT MODELS

Objectives: Current clinical treatment regimes for inflammatory diseases have different drawbacks including side effects of the drugs and the high cost of long term treatment. In the last few decades different promising...

EFFECT OF SUGNIL, A TRADITIONAL ANTIDIABETIC HERBAL FORMULATION ON THE EXPRESSION OF TRANSCRIPTION FACTORS IN STREPTOZOTOCIN DIABETIC RATS.

Objective: A number of large randomized clinical trials demonstrated that lipid lowering successfully reduced cardiovascular events and death in patients with diabetes. Recent studies have reported that multiple transcri...

Download PDF file
  • EP ID EP579004
  • DOI -
  • Views 107
  • Downloads 0

How To Cite

Sangeeta Mohanty, Amit Kumar Panigrahi (2015). MULTIPARTICULATE DRUG DELIVERY SYSTEM FOR COLON TARGETING. International Journal of Pharmacy and Pharmaceutical Sciences, 7(3), 433-436. https://europub.co.uk/articles/-A-579004