Multiple Sclerosis Presenting as Posterior Cortical Atrophy
Journal Title: Dual Diagnosis: Open Access - Year 2017, Vol 2, Issue 2
Abstract
Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome, characterized by insidious and gradual visual impairment in the absence of primary ocular disease [1]. Pathologic studies have revealed that PCA is most often the clinical expression of an atypical form of Alzheimer pathology [2], named the visual variant. More rarely, PCA may be associated to other neurodegenerative etiologies, such as corticobasal degeneration, dementia with Lewy bodies, prion disease (Creutzfeldt-Jakob disease), and subcortical gliosis [1,3-5]. The clinical phenotype may vary according to the etiology, and may include elements of the Balint’s syndrome (optic ataxia, oculomotor apraxia, simultagnosia). Patients complain having inconsistent difficulties to distinguish lines, to read, to estimate distances, and to identify objects. Visual hallucinations are often reported. Clinical onset of PCA is usually observed during the 5th or 6th decades. Diagnosis is usually evoked on a very peculiar neurovisual pattern during cognitive testing and comforted by posterior (occipito-temporo-parietal atrophy on MRI, with clear cortical hypometabolism in the same regions on perfusion PET ou SPECT scans. [6-8]. We describe the case of a patient presenting with PCA syndrome, which was related to an atypical presentation of multiple sclerosis.
Authors and Affiliations
Ehrlé Nathalie, Cason Nia, Vaunaize Jean, Garcia Tony, Bakchine Serge
Keywords
Related Articles
- EP ID EP316438
- DOI 10.21767/2472-5048.100034
- Views 21
- Downloads 0
A Case of Dyskinesia Presenting as Belly Dancer’s Syndrome
Belly dancer's syndrome, also known as diaphragmatic flutter, is a rare condition consisting of involuntary, repetitive contractions of the diaphragm[1]
Pharmacological Models for Short Term Memory Deficiency in Alzheimer ’s disease: First Scopolamine Then Diazepam?
The signature of a drug or disease on the serial position curve of free recall is the item-by-item difference compared with placebo. Early Alzheimer’s disease (average MMSE=26) has one signature, a positive slope, and so...
Women, Boxing & Prejudice, the Facts
Colossal changes have occurred within women’s combat sports in the last two decades, which have challenged society’s perception of women in boxing and mixed martial arts (MMA) [1,2]. Very little research has been produc...
The Present Situation and Problems of a Dotard Family in Korea
The number of dotards over 65 years old based on 2014 in Korea was 610,000 persons, that is, 1 person out of 10 persons. The problem is the family who looks after dementia patients. According to the statistics of health...
Depression and Post-Traumatic Brain Injury: Clinical and Neuropsychological Characteristics
Major depression disorder (MDD) is reported to be the most frequent psychiatric complication after traumatic brain injury (TBI), with a prevalence of 14-77%. The aim of this study was to evaluate the psychiatric consequ...