MULTIPLE UNIT PELLET SYSTEM (MUPS TECHNOLOGY) FOR DEVELOPMENT OF MODIFIED RELEASE FAST DISINTEGRATING TABLETS: A REVIEW
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2017, Vol 6, Issue 3
Abstract
Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in elderly patients, especially since it is difficult to swallow for them. Multiparticulates are the choice of dosage form when fast disintegration is desirable without loss of original release profile. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this review article. It includes not only different types of modified release pellets that can be compressed into Multiple Unit Pellet System (MUPS) but also factors regulating the compression behavior of pellets including properties of pellets, core material, and compressible excipients. This review also presents detailed explanation on physicochemical properties of pellets and formulation strategies of MUPS.
Authors and Affiliations
Nrupa G. Patel, Sandipkumar A. Patel, Abhijeet B. Joshi
Keywords
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- EP ID EP614934
- DOI 10.7897/2277-4572.06352
- Views 52
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