MULTIPLE UNIT SYSTEM: AN APPROACH TOWARDS GASTRORETENTION
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 2
Abstract
Oral drug delivery is the most preferable route due to easy administration, patient compliance, flexibility in formulation and cost effectiveness. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. Over the last few decades several gastro retentive drug delivery approaches have been designed and developed, including high density (sinking) systems, low density (floating) systems, mucoadhesive system, unfoldable, extendible or swellable systems, superporous hydrogel systems, magnetic systems etc. Multiparticulate systems consist of several discrete subunits each containing a portion of drug. Multiparticulate system consists of high density pellets, granules, beads, microballoons, microspheres, mini or micro tablets filled in to sachets, capsules or compressed in to tablets. Multiple unit systems are advantageous over single unit dosage forms due to less possibility of dose dumping and provide more uniform and predictable drug release profile. This review compiles of various types of gastro retentive drug delivery system with special focus on multiple unit gastro retentive systems their method of preparation as well as characterization.
Authors and Affiliations
Swati Gupta , Sushma Singh
Keywords
Related Articles
- EP ID EP104912
- DOI 10.7897/2321-6328.02242
- Views 129
- Downloads 0
A REVIEW ON CLINICAL APPLICATION OF THE CONCEPT OF BALAGRAHA IN MODERN TIMES
Kaumarbhritya is a branch of Astanga Ayurveda that defines a unique concept regarding disease caused by unidentified vectors known as Balagraha. Unfortunately it is abandoned in today’s era due to its mythological explan...
STUDY OF EFFECT OF YOGA ON BREATH HOLDING TIME IN MEDICAL STUDENTS
Yoga is the science of right living which includes postures, breathing exercises and cleansing practices. Yoga consists of five principles which include proper exercise, proper relaxation, proper breathing, proper diet,...
REVISITING GENETICS: THE NEGLECTED PART IN VAJIKARANA
Fertilization is a very complex and fascinating process in which the genetic material of the mother and father unite. It is because of this union of genetic material the children resemble their parents and inherit traits...
INFANT ALCOHOL EXPOSURE - “BAALA MADATYAYA”: AN AYURVEDIC VIEW
Breast feeding is the safest and best method for nurturing and optimising infant growth and health. The risks of drinking alcohol while breast feeding, however are not well defined. Alcohol consumed by a lactating mother...
BIOLOGICAL ACTIVITIES OF DILLENIA INDICA L. BARK GROWING IN BANGLADESH
The study was designed to explore possible phytochemical characteristics (group determinant of plant extract) and to investigate the cytotoxic and anthelmintic potential in vitro, using the methanolic extract of bark of...