MULTIPLE UNIT SYSTEM: AN APPROACH TOWARDS GASTRORETENTION
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 2
Abstract
Oral drug delivery is the most preferable route due to easy administration, patient compliance, flexibility in formulation and cost effectiveness. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. Over the last few decades several gastro retentive drug delivery approaches have been designed and developed, including high density (sinking) systems, low density (floating) systems, mucoadhesive system, unfoldable, extendible or swellable systems, superporous hydrogel systems, magnetic systems etc. Multiparticulate systems consist of several discrete subunits each containing a portion of drug. Multiparticulate system consists of high density pellets, granules, beads, microballoons, microspheres, mini or micro tablets filled in to sachets, capsules or compressed in to tablets. Multiple unit systems are advantageous over single unit dosage forms due to less possibility of dose dumping and provide more uniform and predictable drug release profile. This review compiles of various types of gastro retentive drug delivery system with special focus on multiple unit gastro retentive systems their method of preparation as well as characterization.
Authors and Affiliations
Swati Gupta , Sushma Singh
Keywords
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