NISCH syndrome with hypothyroxinemia

Neonatal Ichthyosis Sclerosing Cholangitis (NISCH) syndrome is a rare autosomal recessive condition characterized by ichthyosis, sclerosing cholangitis and alopecia. Only 5 patients have been described till now. We repor...

Genetic susceptibility to hepatoxicity due to bosentan treatment in pulmonary hypertension

Background. Hepatotoxicity is a major side effect of treatment with bosentan in patients with pulmonary hypertension (PH). Bosentan is metabolized by the cytochrome CYP2C9 and inhibits the bile salt export pump, which is...

Intrahepatic, perihilar and distal cholangiocarcinoma: Management and outcomes

Introduction and aims. Cholangiocarcinomas are a heterogeneous group of tumors that can be classified into three clinically distinct types of cancers, intrahepatic, perihilar and distal cholangiocarcinoma. The inconsist...

Course of a HBsAg positive liver transplantation in a hepatitis B and D virus coinfected recipient

The increasing demand for transplantation has led to consideration of liver grafts from donors exposed to hepatitis B virus (HBV). Six transplantations of liver grafts from hepatitis B surface antigen (HBsAg) positive do...

After 14 years of work and progress