Mycological Profile of Rhinosinusitis in a Tertiary Care Centre
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 3
Abstract
Fungal rhinosinusitis is a common entity encountered with patients admitted in the dept. of ENT. It is caused by a variety of filamentous fungi which can be isolated in culture on saboraud’s Dextrose agar. The disease has significant mortality and morbidity which may be reduced to certain extent by early diagnosis and prompt treatment. So many antifungal agents are available nowadays. Hence in – vitro-antifungal susceptibility testing of the fungal isolates is mandatory to assist the clinician in selection of the appropriate antifungal agent. If it is administered at the proper time complications may be avoided in healthy patients and in case of immunosuppressed, it may be life saving. A study was conducted in the Dept. of Microbiology, Govt. Medical College, Thiruvananthapuram in co-ordination with the Department of ENT for a period of one year from August 2015 to July 2016 to find out the prevalence of Rhinosinusitis and the fungal pathogens causing the disease and the antifungal susceptibility testing of the isolates. A total no. of 186 patients with age group 18 to 80 years and both gender irrespective of the duration of symptoms of Rhinosinusitis were included in the study. Fungal culture positivity was 26.88%. Aspergillus species were the predominant isolates (62%). Aspergillus fumigatus was the most common isolate (41.94%) among the aspergillus species. Antifungal susceptibility testing was performed by microbroth dilution method according to CLSI guidelines. The isolates of Aspergillus species showed 100% sensitivity of Itraconazole, 93.5% sensitivity to Amphotericin B and 100% resistance to Fluconazole. Uncontrolled Diabetes Mellitus was the major risk factor (30%). Mortality rate in our study was 4% which is significantly less when compared to many other studies. This may be because of early detection and treatment with appropriate antifungal drug.
Authors and Affiliations
Dr. Lancy J.
Keywords
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