Mycoplasma pneumoniae infection and macrolide resistance of children hospitalized in Ningbo Areaï¼ Zhejiang Province in 2019â2021
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 2
Abstract
ObjectiveTo investigate Mycoplasma pneumoniae ï¼MPï¼ infection and macrolide resistance of hospitalized children in Ningbo Area in 2019â2021.MethodsA total of 6 782 respiratory throat swab specimens were collected from hospitalized pediatric patients with pneumoniaeï¼ admitted in Ningbo Women and Children's Hospital from Januaryï¼ 2019 to December 2021. MP and its mutations in 23S rRNA were detected by real-time polymerase chain reaction.ResultsAmong 6 782 respiratory throat swab specimens from 2019â2021ï¼ 1 290 cases ï¼19.02%ï¼ were MP positiveï¼ and the positive rate decreased year by year ï¼P<0.05ï¼. The positive rate in 2019 was 28.12%ï¼ higher than that in 2020 ï¼7.16%ï¼ and 2021 ï¼5.16%ï¼ ï¼all P<0.017ï¼. The mutation of 23S rRNA occurred in 947 casesï¼ with a mutation rate of 73.41%. The mutation rate in 2020 was 84.04%ï¼ higher than that in 2019 ï¼73.01%ï¼ and 2021 ï¼66.23%ï¼. The differences of positive rate and mutation rate in different seasons were significant ï¼P<0.05ï¼ ï¼all P<0.008ï¼. The positive rate was the highest in summer ï¼25.00%ï¼ï¼ and the mutation rate was the highest in winter ï¼78.89%ï¼. The positive rate of female children was 20.52%ï¼ higher than that of male children ï¼17.82%ï¼ ï¼P<0.05ï¼ï¼ and the mutation rates of female and male children were 74.93% and 71.77% ï¼P>0.05ï¼ï¼ respectively. The difference of positive rate among the different age was significant ï¼P<0.05ï¼. The positive rates in the 5â and 8â years groups were 27.24% and 26.38%ï¼ higher than those in the 1â and 2â years groupsï¼ respectively. The difference of mutation rate among the four groups in age was not significant ï¼P>0.05ï¼.ConclusionThe infection rate of MP in children decreases in Ningbo Area from 2019 to 2021. MP infection may be related with genderï¼ seasonal distributionï¼ ageï¼ and the resistance rate of MP to macrolide is high.
Authors and Affiliations
LIU Xin,
Keywords
Related Articles
- EP ID EP742073
- DOI -
- Views 24
- Downloads 0
Application and management of human genetic resources in China
Human genetic resources include specimen samples and related information. The application and regulation of human genetic resources in China started at the end of the 20th century and have progressed rapidly. Howeverï¼...
Review on data analysis and application of high-throughput peptide arrays
This article introduces a high-throughput molecular screening chipï¼ peptide arrays. As a kind of biochipï¼ the peptide arrays are easy to synthesisï¼ stable in probe chemistryï¼ high-throughput in screening and high...
Epidemiological trend analysis of liver cancer incidence in Luzhou City, Sichuan Province from 2016 to 2022
Objective To analyze the epidemiological distribution and temporal trends of liver cancer incidence among Luzhou residents from 2016‒2022， and to provide a theoretical basis for improving liver cancer prevention and tre...
Epidemiology and exposure management of rabies in Shanxi Province， 2011‒2022
Objective To analyze the epidemiological features and influencing factors of rabies in Shanxi Province，and to provide evidence to further promote the elimination of rabies in Shanxi Province.Methods The incidence data o...
Analysis of fertility characteristics and trends of registered population in a neighborhood in Jing’ an District，Shanghai from 2013 to 2022
Objective To analyze the fertility characteristics of the registered population in a neighborhood in Jing’an District， Shanghai from 2013 to 2022， and to provide a reference for population development planning and allo...