Mycotoxin MT81 and Its Benzoylated Derivative Exhibit Potential Antisteroidogenic Activities In Prepubertal Female Wistar Rat
Journal Title: Toxicology and Forensic Medicine – Open Journal - Year 2016, Vol 1, Issue 1
Abstract
MT81, a mycotoxin (polyhydroxyanthraquinone, Molecular formula C22 H18 O7) was isolated and identified from Penicillium nigricans. It is highly toxic (LD50 value is 35.1 mg/kg body weight) and shows antimicrobial, antileishmanial activities and produces hepato-renal dysfunction and hematological disorders. The benzoylated derivative of MT81 was synthesized in our laboratory and its LD50 value is 87.1 mg/kg body weight. In spite of its reduced toxicity, the benzoylated derivative (BzMT81) shows potent antimicrobial effects. The present study was aimed to investigate the antifertility activities of Mycotoxin MT81 and its benzoylated derivative on the reproductive system of female prepubertal albino Wistar rats. MT81 and BzMT81 arrested vaginal opening, reduced body weight and the weights of ovaries and uterus. Total cholesterol and ascorbic acid content of the ovaries were elevated whereas the activities of ∆5 -3β-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase were decreased in a dose-dependent manner. In the adrenal gland of rat these parameters showed opposite findings. The study reveals that MT81 and BzMT81 both inhibit ovarian steroidogenesis and causes ovarian sterility in female prepubertal rat but the analogue shows more potentiality.
Authors and Affiliations
Sujata Maiti Choudhury
Keywords
Related Articles
- EP ID EP551397
- DOI 10.17140/TFMOJ-1-101
- Views 121
- Downloads 0
New Psychoactive Substances: Risks and Challenges
New psychoactive substances (NPS) have emerged in the last few years in response to market trends and legislative control. Only in the EU, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) reported in...
Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine
Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control...
Anaphylactic Reactions due to Snakebite Vipera and Administration of Antivenom
A venomous snakebite is the single most important global cause of human injury from venomous and poisonous animals of all types.1 The viper family (Viperaberus, Viperaammodites, Viperaursine)2 is the 2nd most important v...
Mercury Exposure Through Gold Extraction: Varied Signs and Symptoms of Toxicity
A 48-year-old male called the poison control center noting his “skin is starting to peel off”. He stated ten days prior, a container fell from a shelf and spilled approximately 100 milliliters of elemental mercury used f...
Adverse Consequences of Alcohol Consumption: A Preliminary Study
Alcohol is a depressant drug which slows down the activity of the central nervous system (CNS) and cause health related problems associated with various positive and negative social experiences. It has both pharmacologic...