Myeloperoxidase Deficiency: The Secret Under the Flag of Unstained Cell
Journal Title: Turkish Journal of Hematology - Year 2013, Vol 30, Issue 2
Abstract
Myeloperoxidase (MPO) defi ciency is one of the most common inherited phagocyte defects, but it is rarely associated with clinical symptoms [1]. MPO, which is abundant in azurophilic granules of neutrophils and in the lysosomes of monocytes, plays a key role in amplifying the toxicity of hydrogen peroxide generated by the respiratory burst [1,2]. The diagnosis of MPO defi ciency was rare before 1979; currently, the diagnosis is easily made due to the widespread use of automated fl ow cytochemical analysis in clinical hematology laboratories for enumerating peripheral blood neutrophils with peroxidase activity [2].
Authors and Affiliations
Türkan Patıroğlu, Hatice Güngör, Julie Belohradsky, Ekrem Ünal, Christoph Klein
Keywords
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- EP ID EP105718
- DOI 10.4274/Tjh.2012.0012
- Views 83
- Downloads 0
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