MYOCARDIAL DEPRESSANT ACTIVITY OF A NEWLY SYNTHESISED DIHYDROPYRIMIDINE DERIVATIVE 5-ACYL-6-METHYL-4-PHENYL-2-S-ETHYL-1, 4-DIHYDROPYRIMIDINE (BK-vi) IN COMPARISON WITH NIFEDIPINE
Journal Title: International Journal of Medical and Clinical Research - Year 2012, Vol 3, Issue 3
Abstract
Objective- To investigate the myocardial depressant activity of a newly synthesised dihydropyrimidine derivative 5-acyl-6-methyl-4-phenyl-2 -S-ethyl-1,4-dihydropyrimidine (BK - vi) and comparing with nifedipine on Isolated perfused rabbit heart. Material and Methods- Effects of the test compound BK-vi on the amplitude,heart rate and coronary flow on isolated perfused rabbit heart was compared with nifedipine.Observations were made with increasing concentrations of BK-vi and Nifedipine with dimethylsulfoxide (DMSO) as the solvent.Six preparations were used for each dose of BK-vi and nifedipine.Heart rate ,amplitude and coronary flow were noted down every minute for five minutes after injection of each drug and control. Results- On comparing the effects of BK-vi and nifedipine, it was found that both had a negative inotropic and negative chronotropic effect. Compound BK -vi did not produce significant effect on heart rate at all the four doses. In comparison, nifedipine produced a significant to highly significant decrease in heart rate.Significant decrease in amplitude with BK-vi was seen at dose of 7.29 X 10-4M and 14.5 X 10-4M by 42% and 56.98% respectively and in coronary flow by 39.95% at dose of 14.5 X 10-4M .Nifedipine significantly decreased heart rate and amplitude at all doses with cardiac arrest at 4.6 X 10-5M.A significant increase in coronary flow was seen with nifedipine by 9.4% and 13% at doses of 0.5 X 10-5M and 1.15 X 10-5M respectively though this property was lost at higher doses.On comparison, BK-vi produced significant myocardial depression at much higher dose than nifedipine. Conclusion- BK-vi has calcium channel blocking activity like nifedipine and produced less potent myocardial depression in comparison with nifedipine.
Authors and Affiliations
SHALINI SALWAN, POONAM SALWAN, R. WALIA, V. K. BAJAJ, B. KAUR
Keywords
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- EP ID EP170050
- DOI 10.9735/0976-5530.3.3.132-135
- Views 106
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