MYOCARDIAL POTENCY OF AQUEOUS EXTRACT OF HARUNGANA MADAGASCARIENSIS STEM BARK AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL DAMAGE IN RATS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2018, Vol 3, Issue 1
Abstract
The present study was undertaken to evaluate the effects of Harungana madagascariensis on electrocardiographical, biochemical and histopathological changes in isoproterenol (ISO)-induced myocardial infarction in rats. Male Wistar albino rats were randomly divided and treated with the aqueous extract of Harungana madagascariensis stem bark (AEHM, 200 and 400 mg/kg per os), or normal saline or vitamin E for 7 days with concomitant administration of ISO (85 mg/kg, subcutaneously) on 8th and 9th days, at 24 h interval. The ISO injections to the rats caused cardiac dysfunction evidenced by a marked (P<0.01) elevation in ST-segment, a reduction in R wave amplitude (P<0.01), decrease in endogenous antioxidant reduced glutathione (GSH), increase in malondialdehyde (MDA), a lipid peroxidation marker, increase of cardiac marker enzymes lactate dehydrogenase (LDH), aspartate amino transferase (AST) and alanine amino transferase (ALT). All these changes in cardiac function as well as GSH, MDA and the enzymes (LDH, AST and ALT) were ameliorated when the rats were pretreated with AEHM. Additionally, the protective effects were strengthened by improved histopathological changes, which specifies the protection of cardiomyocytes from the deleterious effects of ISO. This study demonstrates the cardioprotective effect of Harungana madagascariensis on isoproterenolinduced myocardial infarction in rats. The mechanism might be associated with the enhancement of antioxidant defense, reduction of lipid peroxydation and it is confirmed by amending electrocardiographic pattern, improvement of cardiac markers and less histopathological damages following ISO-induced myocardial infarction. It could provide experimental evidence to support the use of Harungana madagascariensis used in traditional medicine to treat cardiovascular disorders.
Authors and Affiliations
Esther Ngo Lemba Tom, Florette Diane Nankia, Nyemb Nyunaï
Keywords
Related Articles
- EP ID EP36438
- DOI https://doi.org/10.22270/ujpr.v3i1.R4
- Views 309
- Downloads 0
http://ujpr.org/index.php/journal/article/download/3/1
Because of the high rate of baseline oxygen use by renal cells, kidney is highly influenced by obstruction of arterial blood inflow and subsequent shortage of the received oxygen, this condition is known as Ischemic inj...
PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN
Hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. Therefore, it is important to estimate th...
ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA
Baphia nitida is a tropical plant used in African folkloric medicine for the treatment of infections and inflammatory conditions. This study therefore seeks to investigate the biological activities including antioxidant...
THE PREVALENCE AND PHENOTYPIC CHARACTERIZATION OF EXTENDED-SPECTRUM β-LACTAMASES-PRODUCING ESCHERICHIA COLI STRAINS ISOLATES RECOVERED FROM TERTIARY HOSPITALS IN SANA'A CITY, YEMEN
The emergence of ESBL producing Escherichia coli in clinical isolates is posing a serious threat for treating nosocomial infections. The aim of the study was to determine the frequency of extended spectrum β-lactamase (E...
IDENTIFICATION AND PRIORITIZATION OF BARRIERS TO IMPLEMENT THE GREEN HOSPITAL STANDARDS AT IMAM HASSAN MOJTABA HOSPITAL IN DARAB
One of the most important issues being discussed globally is the environmental protection. The study and review of the standard of the Green Hospital is of particular importance because hospitals are the second most pol...