MYOSTATIN AND ITS ROLE IN THE REGULATION OF MUSCLE MASS AND METABOLISM
Journal Title: Medicina Sportiva - Year 2012, Vol 16, Issue 4
Abstract
Skeletal muscles which constitutes to about 40% of human body despite their role in movement, breathing and heat generation play a central role in whole-body protein, lipid and carbohydrate metabolism. During last years a wealth of studies focused on intracellular signals participating in muscle mass regulation with special attention paid to myostatin (MSTN) also known as growth differentiation factor - 8 (GDF-8). Myostatin mRNA is expressed predominantly in skeletal muscles and to lesser extent in adipose tissue and heart. In addition, relatively high circulating myostatin suggest its systemic action in skeletal muscle where myostatin suppresses cell growth and differentiation by signaling through specific receptors (the activin type IIB receptors - ActRIIB). Myostatin knockout in mice brings about increased myogenesis and muscle hypertrophy, but decreased adipogenesis. Additionally, loss of myostatin in two models of mice obesity (ob/ob, agouti) partially suppressed fat accumulation together with improved glucose disposal and reduced insulin resistance. Both in humans and animals resistance and endurance training brings about decreased mRNA expression in muscles and lower level of circulating myostatin as well as improved insulin resistance. Genetic studies have indicated that myostatin gene mutation or polymorphism at least partially explain the predisposition to exercise demanding strength and/or speed. However, much more studies are needed to eluciadate to which extend myostatin variability contribute to sport performance.
Authors and Affiliations
Grażyna Lutosławska, Joanna Tkaczyk, Anna Kęska
Keywords
Related Articles
- EP ID EP74199
- DOI 10.5604/17342260.1024780
- Views 105
- Downloads 0
COMPARATIVE PERFORMANCE AND LACTATE DATA FROM BENCH PRESSES AT SUBMAXIMAL LOADS
Introduction: Bench presses done at submaximal loads produce localized muscle fatigue that undermines exercise performance. Such changes are manifested through elevated blood lactate concentration ([BLa-]) values. Object...
HYPOXIA AND HEARING – WHAT DO WE REALLY KNOW?
Due to the fact, that the hearing process is an energy-depended and consumptive process, some changes happen, when going to high altitude where the oxygen partial pressure decreases. The oxygen is provided to the inner...
RELATIONSHIP BETWEEN WORKLOAD AND NEUROMUSCULAR ACTIVITY IN THE BENCH PRESS EXERCISE
Objective: To investigate the relationship between strength and electromyographic (EMG) signal in different intensities in the bench press exercise. Methods: Eleven healthy resistance trained men (22.8 ± 3.5) participate...
DEVELOPING AN OBJECTIVE CRITERIA FOR RECOMMENDATIONS TO ATHLETES PRIOR TO A RETURN TO FULL TRAINING FOLLOWING KNEE ACL RECONSTRUCTION
Objective: To determine the cause of the pain and swelling that occurs after a return to training in athletes following reconstruction of the anterior cruciate ligament.Methods: The study involved 42 athletes who had und...
ADAPTATION OF THE ENDOGENOUS INSULIN SECRETION IN NON-INSULIN-DEPENDENT DIABETES BY AN INDIVIDUAL SPORT THERAPEUTIC INTERVENTION – A PILOT STUDY
Objective: To evaluate the effect of a multimodular therapy concept (endurance training, strength training, and diet) on proinsulin in patients with metabolic syndrome and non-insulin dependent diabetes.Methods: Prospec...