N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 3
Abstract
Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. MPO-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils, and the interactions between damaging species involved in the respiratory burst.
Authors and Affiliations
Vânia Noldin, Silvana Vigil, Rafael De Liz, Valdir Cechinel-Filho, Tânia Fröde
Keywords
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