N1,N1,N2,N2-Tetramethylethylenediaminium-N1,N2-disulfonic Acid Trifluoroacetate as Highly Effectual and Dual-Functional Catalyst for the Reaction of β-Ketoesters with Aryl Aldehydes and Urea/Thiourea

Journal Title: Chemical Methodologies - Year 2019, Vol 3, Issue 0

Abstract

In this research, the one-pot multi-component reaction of β-ketoesters with aryl aldehydes and urea/thiourea has been performed using a dual-functional ionic liquid-catalyst namely N1,N1,N2,N2-tetramethylethylenediaminium-N1,N2-disulfonic acid trifluoroacetate ([TMEDSA][TFA]2) in solvent-free conditions. By reason of dual-functionality of the catalyst (possessing acidic and basic sites), and also having two numbers of each site, it was highly effectual and general catalyst, and afforded the products {3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones} in short times with excellent yields. Moreover, a plausible mechanism based on dual-functionality of the catalyst has been proposed.

Authors and Affiliations

Mostafa Karami, Bentolhoda Gholami, Tahereh Hekmat Zadeh, Abdolkarim Zare

Keywords

Related Articles

Synthesis of Pectin Graft Drug to Treatment the Wounds and Inflammations

This idea of this work included preparation new adhesive drug polymers to treatment the wounds and inflammations, new drug polymers were prepared as bio adhesive, which have high viscosity and treatment the wounds by the...

A Facile Synthesis and Docking Studies of N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

A simple method was developed to synthesize N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine by coupling 3-(4-Chlorophenoxy)phenyl)methanamine and 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine. T...

Ultrasonic and Microwave effects on the Benzamide/Sulfuryl Chloride mediated benzoylation of Benzene derivatives under Vilsmeier-Haack conditions

Benzamide/ Sulfuryl Chloride (SO2Cl2) reagent has been developed as a Vilsmeier- Haack(VH) reagent for benzoylation of aromatic compounds under conventional and ultrasonic sonication (US) and microwave (MW) conditions. B...

Theoretical Investigation on the Antitumor Drug: ThioTEPA and its Interaction with S-donor Biomolecules and DNA Purine Bases

During recent years, it has been shown that the thioTEPA molecule can play a very important role as an anticancer drug. The present research studies the structural and spectral properties and reactivity of the thioTEPA a...

Estimation of Anti-dengue Phytochemical Markers Gallic acid, Rutin and Quercetin in Methanolic Extract of Euphorbia hirta (L.) and Tawa-Tawa Capsule Formulation by Validated RP-HPLC Method

Sensitive and precise RP-HPLC method with photo diode array detector has been developed and validated for the simultaneous estimation of three commonly available anti-dengue, anti-cancer and anti-inflammatory phytochemic...

Download PDF file
  • EP ID EP487992
  • DOI 10.22034/chemm.2019.157916.1111
  • Views 64
  • Downloads 0

How To Cite

Mostafa Karami, Bentolhoda Gholami, Tahereh Hekmat Zadeh, Abdolkarim Zare (2019). N1,N1,N2,N2-Tetramethylethylenediaminium-N1,N2-disulfonic Acid Trifluoroacetate as Highly Effectual and Dual-Functional Catalyst for the Reaction of β-Ketoesters with Aryl Aldehydes and Urea/Thiourea. Chemical Methodologies, 3(0), 509-518. https://europub.co.uk/articles/-A-487992