N1,N1,N2,N2-Tetramethylethylenediaminium-N1,N2-disulfonic Acid Trifluoroacetate as Highly Effectual and Dual-Functional Catalyst for the Reaction of β-Ketoesters with Aryl Aldehydes and Urea/Thiourea

Journal Title: Chemical Methodologies - Year 2019, Vol 3, Issue 0

Abstract

In this research, the one-pot multi-component reaction of β-ketoesters with aryl aldehydes and urea/thiourea has been performed using a dual-functional ionic liquid-catalyst namely N1,N1,N2,N2-tetramethylethylenediaminium-N1,N2-disulfonic acid trifluoroacetate ([TMEDSA][TFA]2) in solvent-free conditions. By reason of dual-functionality of the catalyst (possessing acidic and basic sites), and also having two numbers of each site, it was highly effectual and general catalyst, and afforded the products {3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones} in short times with excellent yields. Moreover, a plausible mechanism based on dual-functionality of the catalyst has been proposed.

Authors and Affiliations

Mostafa Karami, Bentolhoda Gholami, Tahereh Hekmat Zadeh, Abdolkarim Zare

Keywords

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  • EP ID EP487992
  • DOI 10.22034/chemm.2019.157916.1111
  • Views 75
  • Downloads 0

How To Cite

Mostafa Karami, Bentolhoda Gholami, Tahereh Hekmat Zadeh, Abdolkarim Zare (2019). N1,N1,N2,N2-Tetramethylethylenediaminium-N1,N2-disulfonic Acid Trifluoroacetate as Highly Effectual and Dual-Functional Catalyst for the Reaction of β-Ketoesters with Aryl Aldehydes and Urea/Thiourea. Chemical Methodologies, 3(0), 509-518. https://europub.co.uk/articles/-A-487992