NAD (P) H: QUINONE OXIDOREDUCTASE 1(NQO1) POLYMORPHISMIN SUDANESE PATIENTS WITH ESSENTIAL THROMBOCYTHAEMIA
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 3
Abstract
Primary or essential thrombocythaemia (ET) is a clonal haemopoietic disorder, it is one of myeloproliferative neoplasm (MPN)that manifests primarily as a marked increase in platelets count with spontaneous aggregation of abnormal functionally platelets.Many genetic polymorphisms are considered as a risk factor in ET. The aim of this study was to examine the association of NQO1 C609T polymorphism with the risk of ET in Sudan. The study included 60 ETpatients, their NQO1 C609T genotypes (PCR/RFLP) and haematological characteristics (Sysmex KX-21N) were determined and compared with 60 age and sex matched normal subjects as control. No significant association was observed between NQO1 mutant genotypes (CT and TT combined together) and the risk of ET (OR= 0.405, 95% CI: 0.131-1.247, P = 0.115). The present study included a relative small sample of patients. Future studies, with large sample size are required to confirm our finding.
Authors and Affiliations
Hiba M. Haneen| Faculty of Medical Laboratory Sciences, Alneelain University, Sudan, Mohamed M. Babekerand| Department of Haematology, Faculty of Medical Laboratory Sciences, Omdurman Ahlia University, Sudan, Mahdi H. A. Abdalla*| Department of Haematology, Faculty of Medical Laboratory Sciences, Omdurman Ahlia University, Sudan
Keywords
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