Nadtlenoazotyn - silny biologiczny utleniacz

Journal Title: Wiadomości Chemiczne - Year 2012, Vol 66, Issue 7

Abstract

As demonstrated in recent years, one of the major factors of oxidative stress, generated in the circulatory system, in both acute and chronic pathological conditions, is peroxynitrite (ONOO –) [4]. Peroxynitrite is a strong biological oxidant and nitrating compound, generated in vivo from a rapid reaction of two relatively less reactive, but commonly found, of free radicals: nitrogen monoxide (NO ) and superoxide (O2–) [8]. This reaction occurs spontaneously and is not catalyzed by any enzyme. A fundamental reaction of ONOO – in biological systems is its fast reaction with carbon dioxide (k = 5,7 ź 104 M–1 s–1) and yields a short-lived intermediate, nitrosoperoxycarbonate (ONOOCO 2 –), which homolyzes leads to the formation of carbonate (CO 3–) and nitrogen dioxide (NO 2) radicals (yield ~35%) [29, 30] (Fig. 1), which are one-electron oxidants. ONOO – is responsible for oxidative modifications in a wide variety of biomolecules and is capable to induce of nitrative changes in sulfur and aromatic amino acids, especially 3-nitrotyrosine and dityrosine formation [17] (Fig. 2). This article describes the formation, reactivity and biological action of peroxynitrite.

Authors and Affiliations

Michał Bijak, Michał Błażej Ponczek, Joanna Saluk, Marta Chabielska, Julita Stępniak, Paweł Nowak

Keywords

Related Articles

Prolina : pospolity aminokwas wyjątkowy katalizator. Część III, Reakcja Mannicha

Mannich reaction occuring among ketone, aldehyde, and amine is one of the ways of a synthesis of biologically active compounds. Reactions of this type were carried out in the presence of different catalysts [3–10], howev...

Nowe termowrażliwe powierzchnie polimerowe do hodowli i uwalniania komórek skóry

ovalent attachment of a thermoresponsive polymer to solid support leads to layers exhibiting temperature-dependent properties. Below the cloud point temperature (TCP) of the thermoresponsive polymer the layer is hydrophi...

Ciecze jonowe oraz potencjalne obszary ich zastosowań w przemyśle chemicznym

Ionic liquids (ILs) compose a group of chemical compounds of ionic nature consisting of organic cation and inorganic or organic anion, whose melting point does not exceed 100°C (373,15 K). These compounds play a very imp...

Peptydoglikan : budowa, rola biologiczna oraz synteza

The most important component of bacterial cell walls especially Gram-positive bacteria is peptidoglycan, called also murein, PGN. The first time this synonym was used in 1964 by Weidel and Pelzer [1]. Peptidoglycan is pr...

Download PDF file
  • EP ID EP590191
  • DOI -
  • Views 121
  • Downloads 0

How To Cite

Michał Bijak, Michał Błażej Ponczek, Joanna Saluk, Marta Chabielska, Julita Stępniak, Paweł Nowak (2012). Nadtlenoazotyn - silny biologiczny utleniacz. Wiadomości Chemiczne, 66(7), 623-635. https://europub.co.uk/articles/-A-590191