Nanosized titanium dioxide material. Modulation of spontaneous motility and gaba-dependent regulation of functions of stomach smooth muscles in vivo
Journal Title: Біологічні Студії - Year 2017, Vol 11, Issue 1
Abstract
Electron scanning microscopy was used to obtain the image and identify the size of TiO2 nanoparticles. Using the tenzometric method in the isometric mode, it was established that chronic effect of TiO2 on stomach smooth muscles led to redistribution of the amplitudes of spontaneous contractions in terms of their frequencies. An increase in frequency of their contractions, decrease in the duration of contraction–relaxation cycle, the disturbance of the asymmetry of the duration of contraction–relaxation development, a reduction in Montevideo index of contractions and Alexandria index of contractions were demonstrated. It was also shown the existance of the divergence in numerical values of frequency-amplitude complexes, TiO2-modified spontaneous contractive activity of smooth muscles of stomach and caecum. In the conditions of long-term chronic influence (100 days), TiO2 removes the regulatory mechanisms of depressing a release of inhibition neuromediators from neurons of the intramural nervous interlacement, mediated by GABAА- and GABAС-receptors, in smooth muscles of stomach and caecum.
Authors and Affiliations
A. M. Naumenko, O. V. Tsymbalуuk, M. A. Skoryk, I. S. Voiteshenko, V. A. Skryshevsky, T. L. Davydovska
Keywords
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- EP ID EP507326
- DOI 10.30970/sbi.1101.520
- Views 144
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