NARCOTIC ANALGESICS: ANGIOPATHIC EYE CHANGES IN RATS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2017, Vol 49, Issue
Abstract
Pain constitutes up to 90% of all patient complaints in primary health care, so effective pain control and proper drug therapy are relevant problems. However, besides the appropriate use of analgesics for pain control, the gross misuse of analgesics a growing epidemic recent years. The prevalence rate of opioid use (at least once a year) is 61.0/ per 1000 adults in the USA and up to 27.0/ per 1000 adults in Europe (RecoveryBrands, 2013). According to the data of UNODC (United Nations Offi ce on Drugs and Crime) total number of individuals using opioids attained 33 million people in 2014. Modeling of the long-term effect of narcotic analgesics was performed by using a semi-synthetic opioid analgesic Nalbuphine. The study was carried out on 48 mature white male rats aged 3.0-3.1 months and with the body weight 160-180 g. All experimental procedures were approved by the University Animal Care and Use Bioethical Committee. The studies were conducted with application of morphological, in particular, histological, electron microscopy and morphometric methods of investigation; mathematical; modeling the prolonged effect of the opioid. The research material was presented by the specimens of the eyeball vascular tunic, consist of the iris, ciliary body and choroid.
Authors and Affiliations
U. Pidvalna, L. Mateshuk-Vatseba, A. Kost, O. Dzhura
Keywords
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