Nasal Manifestations in Granulomatosis with Polyangiitis: A Case Report and Review of the Literature
Journal Title: Otolaryngology – Open Journal - Year 2018, Vol 4, Issue 2
Abstract
Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexisting glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent functional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagnosis of GPA is important to initiate therapy which may be life-saving and organ sparing.
Authors and Affiliations
Massimo Ralli
Keywords
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- EP ID EP536267
- DOI 10.17140/OTLOJ-4-149
- Views 152
- Downloads 0
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