Nasal Manifestations in Granulomatosis with Polyangiitis: A Case Report and Review of the Literature
Journal Title: Otolaryngology – Open Journal - Year 2018, Vol 4, Issue 2
Abstract
Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexisting glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent functional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagnosis of GPA is important to initiate therapy which may be life-saving and organ sparing.
Authors and Affiliations
Massimo Ralli
Keywords
Related Articles
- EP ID EP536267
- DOI 10.17140/OTLOJ-4-149
- Views 165
- Downloads 0
Chronic Otitis Media with Facial Palsy: An Unexpected Etiology
Chronic otitis media is a commonly observed disease worldwide. Facial palsy in a patient can be attributed to many causes. Facial paresis with chronic otitis media is almost always attributable to facial palsy. This arti...
The First Case of Endoscopic Transnasal Removal of an Ectopic Molar Tooth from the Pterygomaxillary Fossa: A Low Morbidity Approach
Ectopic teeth erupted in the maxillary sinus (MS) or Pterygomaxillary Fossa (PF) are rarely reported. Though often asymptomatic, patients with ectopic teeth in the MS or PF may suffer from facial pain/numbness, purulent...
Migratory Foreign Bodies in the Neck: Possible Role for Endoscopic Surgery
Foreign body ingestion is a common ENT emergency case among the pediatric population. Most of the ingested foreign bodies pass naturally through the gastrointestinal (GI) tract without any complications; however, in abou...
Preliminary Findings on Gender Differences in Aesthetic Rhinoplasty Patients: Body Appreciation and Appearance Comparisons
Objective: Body image has a crucial role in considering elective aesthetic surgery. Yet, gender differences have not been well studied in this respect. The present study aimed to provide preliminary comparisons between m...
An Unusual Entity of Sarcoidosis: Acute Parotitis
Sarcoidosis is a rare systemic granulamatous disease of unknown etiology that may effect many organ and system, mainly lungs. This disease is rare in children. Sarcoidosis is staging contingent on posterior-anterior ches...