NATURAL ANTIMICROBIALS IN THE PIPELINE AND POSSIBLE SYNERGISM WITH ANTIBIOTICS TO OVERCOME MICROBIAL RESISTANCE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 4
Abstract
The unresponsive use of antibiotics led to the appearance of multiple drug-resistant bacteria strains. Studying the mechanism by which bacteria can resist antibiotics, the so called quorum sensing and biofilm formation, enabled the researchers to find bioactive compounds, derived from eukaryotes and prokaryotes. The disrupt of this mechanism is called quorum sensing inhibitors or quorum quenchers. This article provides an overview on the current research done on such bioactive compounds, the possible use of them as antibiotic alternatives, what are the advantage and disadvantages, the source from which it has been extracted, and how it may succeed to overcome bacterial resistance. The recommendation of researchers is to use some of these natural antimicrobial compounds combined to lower doses of antibiotics for treatment, the fastest way to limit the adverse effects of the exploitation of antibiotics and to avoid bacterial resistance.
Authors and Affiliations
EMTENAN M HANAFI , ENAS N DANIAL
Keywords
Related Articles
- EP ID EP604649
- DOI -
- Views 95
- Downloads 0
PARVIMONAS MICRA AND FUSOBACTERIUM NUCLEATUM SEPTIC ARTHRITIS: A RARE ANAEROBIC DOUBLE TROUBLE
Septic arthritis is a condition initiated by pathogenic inoculation of joints either by direct or hematogenous route, necessitating immediate medical attention. Among aerobic bacteria, Staphylococcus aureus and Streptoco...
ANTICANCER POTENTIAL OF α-MANGOSTIN
Objective: Mangosteen (Garcinia mangostana Linn.) is a tropical fruit originated from South East region. Mangosteen exhibiting a variety of pharmacological activities and is often used for traditional medicine. There are...
CEFTRIAXONE-INDUCED PERIORBITAL EDEMA
Cephalosporins are widely prescribed antibiotics for common infections and also used for prophylactic measures. Ceftriaxone is a third-generation cephalosporin which is known to cause hypersensitivity reactions presentin...
THE EFFECT OF EXTRACT OF DATE PALM FRUIT (PHOENIX DACTYLIFERA L.) ON FERTILITY IN MALE MICE (MUS MUSCULUS L.)
Objective: Date palm is one of the plants that have used empirically to increase fertility. Ethanol induction can cause sperm damage in male mice. Sperm damage is one of the infertility agents. The aim of this study was...
PHENOLIC ACID PROFILING IN THE LEAVES OF TABERNAEMONTANA HEYNEANA WALL. AN ENDEMIC PLANT OF THE WESTERN GHATS USING ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH QUADRUPOLE-TIME-OF-FLIGHT
Objectives: The study was conducted to identify the phenolic compounds and other possible bioactive compounds present in the leaf extracts of Tabernaemontana heyneana Wall. Methods: Phenolic acid profiling was carried o...