Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 12
Abstract
Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceraltype leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. For its treatment, pentavalent antimonial drugs are administered. These drugs cause severe side effects, are costly. Drug-resistant cases have been reported and have been developing for over 70 years. One alternative to the drugs that are currently available is to find active molecules in medicinal plants. Dihydrocorynantheine, corynantheine and corynantheidine are active against Leishmania major, while harmane, pleiocarpin, buchtienin, luteolin and quercetin are active against Leishmania donovani. In Mexico, about 20 medicinal plants have been evaluated against Leishmania mexicana, among which the most active are Tridax procumbens, Lonchocarpus xuul and Pentalinon andrieuxii. From these plants, active compounds with IC50 30 mg/mL or mM have been isolated, such as 3(S)-16,17-didehydrofalcarinol or Oxylipin, cholestra-4,20,24-trien-3-one or pentalinosterol, 24-methylcholest-4-24(28)- dien-3-one, cholest-4-en-3-one, 6,7-dihydroneridie-none, neridienone, cholest-5,20,24- trien-3b-ol, and isocordoin. Today, only pentalinonsterol has been synthesized and assayed in the visceral leishmaniasis experimental model using BALB/c mice infected with Leishmania donovani. Liposome formulation of this compound administered by intravenous route at 2.5 mg/kg showed a significant reduction of parasite load in mouse liver and spleen.
Authors and Affiliations
Gabriel Alfonso Guti´errez-Rebolledo,
Keywords
Related Articles
- EP ID EP250413
- DOI 10.1016/j.apjtm.2017.10.016
- Views 87
- Downloads 0
Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain
Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods: Rotenone was administered in a do...
Novel neuroprotective and hepatoprotective effects of citric acid in acute malathion intoxication
Objective: To study the effect of citric acid given alone or combined with atropine on brain oxidative stress, neuronal injury, liver damage, and DNA damage of peripheral blood lymphocytes induced in the rat by acute mal...
Biotechnological intervention in betelvine (Piper betle L.): A review on recent advances and future prospects
Betelvine (Piper betle L.) is cultivated for its deep green heart shaped leaf for (15–20) million Indian and 2 billion foreign consumers annually. The crop provides Rs (6 000– 7 000) million of national income per year a...
Herbal remedies, vaccines and drugs for dengue fever: Emerging prevention and treatment strategies
Dengue fever is a disease that is caused by five dengue virus (DENV) serotypes. It is endemic in more than 128 countries. Millions of people are affected by this disease. But still, there is no specific treatment avail...
A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment
Objective: To discuss the effect of lesser-known potential risk factors, such as bedroom showers, on the prevalence of allergic rhinitis. Method: A cross-sectional, population-based study was performed using both survey...