Natural Product Synthesis and Drug Discovery: Shortcomings and Successes
Journal Title: Tropical Journal of Natural Product Research - Year 2017, Vol 1, Issue 1
Abstract
Natural products have evolved over the years and several of them have been found to interact with biological macromolecules in intact organisms. Their structural complexity often makes it difficult to produce natural drug molecules via chemical synthesis. This limitation can hinder their further development as drugs. Modification of a natural product’s structure by chemical synthesis to address issues of unwanted side effects can also be very difficult. As an alternative to chemical synthesis, the natural products are isolated in commercial quantities from their sources. This however, poses other challenges such as the need to obtain enough raw material in an environmentally sustainable fashion to ensure an adequate supply of the drug. There is also variability in how some substances produce often trace amounts of potential drugs. In the pharmaceutical industry, such drawbacks have led to the deprioritization
Authors and Affiliations
Lee Pedzisa
Keywords
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- EP ID EP349808
- DOI 10.26538/tjnpr/v1i3.1
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