NATURAL REMEDIES TARGET DIFFERENT THERAPEUTIC PATHWAYS IN ORAL MUCOSITIS INDUCED BY CANCER CHEMO OR RADIOTHERAPY
Journal Title: International Journal of Pharmacognosy - Year 2017, Vol 4, Issue 8
Abstract
Oral mucositis (OM) is an inflammatory condition affecting oral mucosa. The etiology of this type of inflammation is associated with exposure to radiotherapy or chemotherapeutic drugs. Herbal drugs have been used to induce healing of different types of gastrointestinal ulcers. The role of medicinal plant in cancer therapy induced oral mucositis has been investigated extensively. Preclinical studies refer to healing activity of some medicinal plants such as Chamomile, royal jelly, Calendula officinalis and salvadora perisca in oral mucositis induced by either chemotherapy or radiotherapy. Some herbal drugs are proved to have potential efficacy in decreasing both incidence and severity of oral mucositis in clinical studies. The molecular targets modulated by herbal drugs are various including scavenging reactive oxygen species (ROS), Inhibition of inflammatory cascade, prevention of keratinocyte apoptosis and induction of some growth factors. This review illustrates the common herbal drugs that have been used for oral mucositis management focusing on different therapeutic pathways that are implicated in this pharmacologic activity.
Authors and Affiliations
Sherin Zakaria
Keywords
Related Articles
- EP ID EP428717
- DOI -
- Views 72
- Downloads 0
GREEN NANOPARTICLE SYNTHESIS AND THEIR APPLICATIONS
As we are well aware that the production of metallic nanoparticles by the physical and chemical method has numerous drawbacks along with the use of toxic chemicals, high energy expenditure and non- biodegradable products...
ANATOMICAL STUDIES ON LEAF OF CADABA FRUTICOSA (L.) DRUCE
Cadaba fruticosa (L.) Druce belongs to the family Capparaceae. It is woody, erect, glandular- pubescent shrubs. It is used in the folk system of medicine. Anti-rheumatic, anthelmintic and antibacterial properties it is a...
CURRENT REVIEW ON BIOTECHNOLOGICAL AND PHARMACOLOGICAL INVESTIGATIONS OF SIMAROUBA GLAUCA-AN OIL YIELDING PLANT.
Simarouba glauca is one of the important herbal drugs used against dysentery and has a long history in herbal medicine in many countries. The bark and leaf extract of Simarouba is well known for its different types of ph...
MEDICINAL PLANTS SUPPORT THE AMYLIN-SUPPRESSED VIABILITY OF ISLET β-CELLS
The proliferation of β-cells is the main contributor to the mass cell maintenance in the pancreatic islets. In our earlier work the suppression of β-cell growth by aggregated peptide hormone of the pancreas, amylin, has...
TRADITIONAL MEDICINAL USES, PHYTOCHEMICAL PROFILE AND PHARMACOLOGICAL ACTIVITIES OF LUFFA ACUTANGULA LINN.
Inflammation is a body defense reaction to prevent the spread of injurious agent and to remove the necrosed cells and tissues. Inflammatory abnormalities are a large group of disorders which underlie a vast variety of hu...